CDKN1B, cyclin dependent kinase inhibitor 1B, 1027

N. diseases: 454; N. variants: 20
Disease: melanoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE Moreover, a series of functional assays demonstrated that mir-221 could directly inhibit cKit, p27(Kip1) and, possibly, other pivotal proteins in melanoma. 19126397 2009
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE Reduced Cks1 or Skp2 expression and enhanced p27(Kip1) levels inhibit melanoma cell growth. 16924241 2007
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease LHGDN Here we provide evidence that p15(INK4b), rather than p27(KIP1), is the cyclin-dependent kinase inhibitor responsible for G0/G1 arrest of human melanoma cells grown on fibrillar collagen. 17553787 2007
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease LHGDN Reduced expression of p16 and p27 is correlated with tumour progression in cutaneous melanoma. 18027257 2007
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE This review summarises the current knowledge of alterations in these two pathways at G1/S transition and specifically the role of the key cell cycle regulatory proteins pRb, p16INK4a (p16), cyclin D1, p27Kip1 (p27), p53 and p21Waf1/Cip1 (p21) in the pathogenesis of melanoma. 16916716 2006
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE Thus, adhesion-growth factor cooperation, leading to efficient activation of ERK, regulates cyclin D1 and p27Kip1 levels in human melanocytes and mutant BRAF overrides adhesion-growth factor control of these two G1 cell cycle proteins in melanomas. 15735667 2005
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease LHGDN We therefore examined by immunohistochemistry the expression of Skp2, p27KIP1 and Ki-67 in 10 naevi (Ns), 15 superficial spreading melanomas (SSMs), 10 nodular melanomas (NMs) and 14 melanoma metastases (Ms). 15736055 2005
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease LHGDN Expression of p27 and MAPK proteins involved in all-trans retinoic acid-induced apoptosis and cell cycle arrest in matched primary and metastatic melanoma cells. 15492811 2004
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease LHGDN Expression of cell cycle inhibitor p27Kip1 and its inactivator Jab1 in melanocytic lesions. 15154004 2004
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE Taken together, our data shows that loss of p27KIP1 protein expression and LOH at 12p13 contribute to tumour progression in melanoma. 15205952 2004
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker disease BEFREE Cyclin E, p21(Waf-1) and p27(Kip-1) are also elevated in many primary melanomas, whereas p16(INK4a) is mutated or deleted in many invasive and metastatic melanomas. 11602203 2001
CUI: C0025202
Disease: melanoma
melanoma 		0.100 PosttranslationalModification disease BEFREE Collectively, our data suggest that DNA methylation may be a cause of monoallelic p27Kip1 silencing in malignant melanoma, which would support a role for p27Kip1 haploinsufficiency in human cancer. 11042700 2000
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression disease BEFREE In the present study, we utilized an adenoviral vector-based expression system to examine the consequences of p27Kip1 overexpression in the human carcinoma cell lines A549, HeLa and RKO, in human melanoma SK-MEL-110 cells, in human lung fibroblasts IMR90 and in the rat fibroblast line Rat1. 9416843 1997