|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, the presence and load of somatic hypermutation (SHM) within the rearranged IG heavy variable (IGHV) gene occurring as during B-cell development of germinal center and post-germinal center lymphomas may hamper appropriate primer binding leading to false-negative results.
|
30779036 |
2019 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
We confirmed previous reports that HCV-associated lymphomas use a restricted immunoglobulin variable region gene repertoire.
|
24449209 |
2014 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
IGHV gene features and MYD88 L265P mutation separate the three marginal zone lymphoma entities and Waldenström macroglobulinemia/lymphoplasmacytic lymphomas.
|
22944768 |
2013 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results indicate that the relatively constant epitope in the IgHV FR may be useful for immunotherapy of lymphomas with the same IgHV subfamily.
|
21657960 |
2011 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Overall our findings demonstrate that C. psittaci-negative ocular adnexal EMZL exhibit biased usage of IGHV families and genes with evidence for intraclonal heterogeneity and antigen selection in multiple tumors, implicating B-cell receptor-mediated antigen stimulation in the pathogenesis of these lymphomas.
|
22216179 |
2011 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Our results showed that BIOMED-2 IGK assays are significantly more sensitive than IGH assays in follicular lymphoma due to the fact that the rearranged IGKV is less frequently targeted by somatic hypermutation than IGHV, and therefore, are essential in routine clonality analysis of these lymphomas.
|
21790530 |
2011 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
The heterogeneous representation of IGHV genes in HIV-NHL may be related to specific pathways of antigen stimulation, or to differences in host's immune dysregulation and lymphoma histogenesis.
|
18556404 |
2008 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In classic RT, 18/23 B-CLL cases (78%) showed clonal progression to DLBCL with identical IgVH sequences in both lymphoma components, whereas in 5 cases (22%) the DLBCL was clonally unrelated.
|
17895764 |
2007 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Clinical trials of IgHV protein vaccines against lymphoma have demonstrated induction of tumor-specific cytotoxic T lymphocyte (CTL) responses.
|
17517179 |
2007 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Persisting monoclonal bands for immunoglobulin heavy chain variable region (VH) representing the lymphoma clone have been described in up to 50% of patients in CR.
|
15284253 |
2004 |
|
Lymphoma
|
0.100 |
Biomarker
|
group |
BEFREE |
In three of five patients who had interpretable results, a distinct, monoclonal, VH family-specific band profile was obtained from the cerebral and systemic lymphoma.
|
15372481 |
2004 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease.
|
12609845 |
2003 |
|
Lymphoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Immunoglobulin heavy chain variable region family expression in primary cutaneous follicle centre cell lymphomas.
|
11298550 |
2001 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
To further elucidate the role of antigen selection in the evolution of gastric low-grade MALT-type lymphoma, we analyzed intraclonal variations of the immunoglobulin heavy-chain variable region (Ig VH) genes expressed in three cases of lymphoma.
|
9111510 |
1997 |
|
Lymphoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Examination of the mRNA species expressed from the IgT gene in this lymphoma shows a variety of forms but all IgT mRNA include the T cell-specific exon, ET, previously located in the distal part of the VH locus.
|
1339353 |
1992 |