|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We also found immunoglobulin variable region genes that were disproportionally used to encode clonal B-cell receptors (BCRs) in the tumors.
|
30617194 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Notably, following the combined therapy all patients showed induction/enhancement of T-cell responses by CD107 degranulation or IFNγ ELISPOT assay against patient-specific tumor IGHV sequences.
|
31171545 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The clonal DNA IGHV sequence of the tumor was aligned and compared with the closest germline sequence and homology percentage was calculated.
|
28838616 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunoglobulin IGHV genes carry imprints of clonal tumor history, delineating somatic hypermutation (SHM) events that generally occur in the germinal center (GC).
|
25929340 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
U-2932 populations were traced to subclones of the original tumor with clone-specific immunoglobulin IgVH4-39 hypermutation patterns.
|
23295736 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor immunoglobulin heavy chain variable region was more frequently unmutated in CLL cells of LR patients, and the mevalonate pathway, which generates Vγ9Vδ2 TCR ligands, was more active in unmutated CLL cells.
|
22932792 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The histology, immunophenotype, immunoglobulin variable region (IgV) gene somatic hypermutation status, and the pattern of genetic alterations of the tumor cells are markedly distinct from that of any other B-cell tumor.
|
21029776 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Patients with iMCL displayed nonnodal leukemic disease with predominantly hypermutated IGVH and noncomplex karyotypes. iMCL and cMCL shared a common gene expression profile that differed from other leukemic lymphoid neoplasms.
|
20124476 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Accurate assessment of the somatic mutational status of clonal immunoglobulin variable region (IgV) genes is relevant in elucidating tumour cell origin in B-cell lymphoma; virgin B cells bear unmutated IgV genes, while germinal centre and postfollicular B cells carry mutated IgV genes.
|
19906071 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunoglobulin variable region gene analysis to the autoantibody-secreting B cells from tumors in association with paraneoplastic autoimmune multiorgan syndrome.
|
17988333 |
2007 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In the 28 cases available for genetic studies, low CXCR3 expression also showed good concordance with tumor unmutated IgVH gene status (p<0.04), and tended to correlate with high CD38 expression (p<0.06).
|
17339184 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Clinical trials of IgHV protein vaccines against lymphoma have demonstrated induction of tumor-specific cytotoxic T lymphocyte (CTL) responses.
|
17517179 |
2007 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In three cases, genealogical trees were constructed based on the immunoglobulin variable region heavy chain (IgV(H)) gene sequences of tumor clones from LNs and BMs.
|
15973453 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the other two patients, a similar VH band pattern was observed and also was compared using direct sequencing, which demonstrated sequence differences between tumors from the two sites.
|
15372481 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Previous studies have demonstrated that, in addition to IgG Fc receptors, the human myeloid IgA receptor (Fc(alpha)RI, CD89) also effectively triggered tumor cell killing.
|
12393717 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Insight into the origin and clonal history of B-cell tumors as revealed by analysis of immunoglobulin variable region genes.
|
9602369 |
1998 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunoglobulin heavy chain variable region family usage is independent of tumor cell phenotype in human B lineage leukemias.
|
1700749 |
1990 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We have previously shown that the cytogenetic breakpoints of one t(14;14)(q11;q32) chromosome and two inv(14)(q11;q32) chromosomes in T-cell tumors from AT and non-AT patients join the T-cell receptor alpha chain locus, at chromosome band 14q11, with a region(s) at 14q32 centromeric of the immunoglobulin heavy chain variable region (VH) gene IGHV.
|
3194418 |
1988 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The immunoglobulins secreted by these cell lines reacted variably with a panel of anti-idiotypic antibodies, indicating that the tumor was heterogeneous; however, one antibody, 4D6, reacted strongly with the product of all the heterohybridomas. cDNA for the immunoglobulin heavy chain variable-region genes expressed in these heterohybridomas was cloned and sequenced.
|
3496601 |
1987 |