|
Abdominal Pain
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of the lymphatic system
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Abscess of peritoneum
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Acanthosis palmaris
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Receptor tyrosine kinase and p16/CDKN2 expression in a case of tripe palms associated with non-small-cell lung cancer.
|
10640836 |
1999 |
|
Acinar cell carcinoma of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
Concurrent loss of p53 and Ink4a/Arf resembles loss of p53 alone, suggesting that Ink4a/Arf loss has no additive effect to PACC progression.
|
27664376 |
2016 |
|
Acoustic Neuroma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
P14ARF deficiency and its correlation with overexpression of p53/MDM2 in sporadic vestibular schwannomas.
|
24964769 |
2015 |
|
Acral Lentiginous Malignant Melanoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Loss of expression of p16 is associated with lower levels of CD3+ and CD8+ TIL, indicating a probable relationship between p16 and TIL immune response in ALM .
|
30778854 |
2019 |
|
Acral Lentiginous Malignant Melanoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Acral Spitz nevi were characterized by strong and diffuse P16 and P21 expression, which differs from acral nevi and acral lentiginous melanoma.
|
29537991 |
2018 |
|
Acromegaly
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Tumor ARF mRNA expression measured at the time of the surgery is a prognosis factor in acromegaly.
|
30975543 |
2019 |
|
Acromegaly
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
However, the expression of the p16 protein was lower than in the NFA group than in the CD and acromegaly groups (p = 0.030, p = 0.033, respectively), and E2F1 protein expression was significantly higher in the NFA group than in the CD group (p = 0.025). p73 protein expression in patients with acromegaly was significantly higher (p = 0.031) than that in the CD group.
|
31828584 |
2020 |
|
ACTH-Secreting Pituitary Adenoma
|
0.030 |
PosttranslationalModification
|
disease |
BEFREE |
Tissue from 31 corticotroph adenomas and 16 nonadenomatous pituitaries were subject to methylation-sensitive PCR to determine the methylation status of the p16 gene CpG island.
|
15014032 |
2004 |
|
ACTH-Secreting Pituitary Adenoma
|
0.030 |
PosttranslationalModification
|
disease |
BEFREE |
The mechanisms of p16 down-regulation probably involve CDKN2A methylation in most types, but remain to be determined in somatotroph and corticotroph adenomas.
|
11276008 |
2001 |
|
ACTH-Secreting Pituitary Adenoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Thus, it is suggested that upregulated CDKN2A with the concomitant downregulated cyclin gene family is partly involved in the small size of ACTH-secreting adenoma.
|
20616110 |
2010 |
|
Actinic keratosis
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of p16INK4a was detected in a subset of dysplastic cells (10% to 80%) of all skin (pre)cancer lesions such as actinic keratoses, SCC in situ, Bowen's carcinoma, and SCC infected with HPV independent of sun exposure.
|
15008871 |
2004 |
|
Actinic keratosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
The evaluation of a large number of AK specimens in this study have found a low gene mutation rate in low-graded AK lesions. p53 mutations rather than p16(INK4a) and/or Ha-ras mutations may be an early event in the development of AK to cutaneous SCC.
|
17488404 |
2007 |
|
Actinic keratosis
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Finally, the absence of differences in p53 and p16 expressions is at variance with other epithelia where the classical pathway is associated with human papillomavirus infection and can be explained by the fact that both AK pathways share identical mechanisms of actinic oncogenesis.
|
28796927 |
2018 |
|
Actinic keratosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Single strand conformation polymorphism and sequencing analysis of the p53 and INK4a-ARF genes were carried out in DNA from normal skin and different tumors (four actinic keratosis, two microinvasive squamous cell carcinomas, one basal cell carcinoma, and one atypical fibroxanthoma) from the patient.
|
12485439 |
2002 |
|
Actinic keratosis
|
0.090 |
GeneticVariation
|
disease |
LHGDN |
Low prevalence of p53, p16(INK4a) and Ha-ras tumour-specific mutations in low-graded actinic keratosis.
|
17488404 |
2007 |
|
Actinic keratosis
|
0.090 |
Biomarker
|
disease |
LHGDN |
Genomic instability, mutations and expression analysis of the tumour suppressor genes p14(ARF), p15(INK4b), p16(INK4a) and p53 in actinic keratosis.
|
18331779 |
2008 |
|
Actinic keratosis
|
0.090 |
AlteredExpression
|
disease |
LHGDN |
All 10 actinic keratoses were positive for weak to moderate p16 staining in the lower third to lower half of the epidermis (especially the basal keratinocytes).
|
12429789 |
2002 |
|
Actinic keratosis
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
The aims of this study were to assess (1) the relation between risk factors for carcinogenesis, sun exposure and immune status, and p16 or p53 expression, and (2) to assess differences in p16 and p53 expression between KINs and SCCs.
|
13679450 |
2003 |
|
Actinic keratosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Two AK samples carried a not-previously described non-UV type missense mutation at codon 184 (Val184Glu) of exon 1b in the p14(ARF) gene.
|
18331779 |
2008 |
|
Actinic keratosis
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Our results imply that progression of AK into SCC may involve inactivation of p16(INK4a).
|
11804749 |
2002 |
|
Actinic keratosis
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Six different mutations (12%) were detected in exon 2 of p16 (common to p16alpha and p16beta), in five out of 21 squamous lesions (24%) (one AK and four SCCs) and one out of 28 BCCs (3.5%).
|
10498902 |
1999 |
|
Acute leukemia
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Epigenetic inactivation of INK4/CDK/RB cell cycle pathway in acute leukemias.
|
14513284 |
2003 |