|
Keloid
|
0.010 |
Biomarker
|
disease |
BEFREE |
A raised scar with the CD34<sup>-</sup> /α-SMA<sup>+</sup> /p16<sup>+</sup> phenotype with strong immunoreactivity for p16 and significant amounts of keloidal collagen, together with a thickened and strongly abnormal involucrin-stained epidermis, would sway the diagnosis towards keloid scars.
|
31206605 |
2020 |
|
Odontogenic Cysts
|
0.010 |
Biomarker
|
disease |
BEFREE |
No significant difference in p16INK4a staining was noted between odontogenic cysts and the listed odontogenic tumors (chi-square, P = .540).
|
31680334 |
2020 |
|
Squamous metaplasia of cervix
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our study demonstrates that p16 positivity in squamous metaplasia of cervix is associated with the presence of transcriptionally active high-risk HPV even when there are no clear morphologic features of dysplasia.
|
31498174 |
2020 |
|
Jaw Keratocyst
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Prior studies have evaluated p16INK4a expression in odontogenic keratocyst and ameloblastoma, but data regarding other odontogenic cysts and tumors have been sparse.
|
31680334 |
2020 |
|
Carcinomatosis of peritoneal cavity
|
0.010 |
Biomarker
|
disease |
BEFREE |
BAP1 immunohistochemical and CDKN2A fluorescent in situ hybridization (FISH) techniques were performed on tissue specimens of DMPM (n=48) and peritoneal carcinomatosis (n=71) then on cell-block of DMPM (n=16), peritoneal carcinomatosis (n=25) and peritoneal benign effusion (n=5).
|
31713897 |
2020 |
|
Non-alcoholic Fatty Liver Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Then the HFD-induced NAFLD mice were treated with vitamin D. Next, the serum levels of TNF-α, GSH-px and malondialdehyde (MDA) were assessed using ELISA and ROS content was evaluated by flow cytometry, followed by the measurement of expression of Duox1, Duox2, SOD1, SOD2, PRDX1 I, ACC, SREBP1c, MTTP, PPARα, p53, p21 and p16 using RT-qPCR and Western blot analysis.
|
31756344 |
2020 |
|
Carcinoma of peritoneum
|
0.010 |
Biomarker
|
disease |
BEFREE |
CDKN2A loss was observed in 34.9% DMPM and 2.1% peritoneal carcinoma.
|
31713897 |
2020 |
|
Peritoneal Mesothelioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
BAP1 immunostaining represents an objective and reproducible diagnostic biomarker for peritoneal mesothelioma in effusion cytology specimens and should be preferred to CDKN2A FISH analysis on these precious samples.
|
31713897 |
2020 |
|
Keratocystic Odontogenic Tumor
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Prior studies have evaluated p16INK4a expression in odontogenic keratocyst and ameloblastoma, but data regarding other odontogenic cysts and tumors have been sparse.
|
31680334 |
2020 |
|
Congenital dyserythropoietic anemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In addition, uptake of bromodeoxyuridine by CDA-erythroid cells was significantly decreased at the CD235a<sup>+</sup>/CD71<sup>+</sup> stage, and microarray analysis revealed that cell cycle regulator genes were dysregulated, with increased expression of negative regulators such as CDKN2C and CDKN2A.
|
30876823 |
2019 |
|
Congenital arteriovenous malformation
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Methylation of the CDKN2A Gene Increases the Risk of Brain Arteriovenous Malformations.
|
31325108 |
2019 |
|
Diarrhea
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Across p16 status and smoking history subgroups, the most common treatment-related adverse events (AEs) were diarrhea (70-91%), rash/acne (72-84%), stomatitis (34-73%) with afatinib; and included stomatitis (39-100%), fatigue (22-50%), nausea (19-36%) with methotrexate.
|
31450171 |
2019 |
|
Fatigue
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Across p16 status and smoking history subgroups, the most common treatment-related adverse events (AEs) were diarrhea (70-91%), rash/acne (72-84%), stomatitis (34-73%) with afatinib; and included stomatitis (39-100%), fatigue (22-50%), nausea (19-36%) with methotrexate.
|
31450171 |
2019 |
|
Leukoplakia, Oral
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overexpression of p16 was not found to be a reliable biomarker for HPV infection in patients with OL and OSCC.
|
30842161 |
2019 |
|
Dental Fluorosis, Acquired
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
These results reveal a regulatory role of p16 gene methylation on osteoblasts activation during the development of skeletal fluorosis.
|
30259626 |
2019 |
|
Nausea
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Across p16 status and smoking history subgroups, the most common treatment-related adverse events (AEs) were diarrhea (70-91%), rash/acne (72-84%), stomatitis (34-73%) with afatinib; and included stomatitis (39-100%), fatigue (22-50%), nausea (19-36%) with methotrexate.
|
31450171 |
2019 |
|
Neurodermatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
CVIN with superimposed LSC demonstrated intense p16 positivity extending from the basal cells to the mid-epithelium and a reduction or loss of staining in maturing keratinocytes.
|
29750709 |
2019 |
|
Stomatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Across p16 status and smoking history subgroups, the most common treatment-related adverse events (AEs) were diarrhea (70-91%), rash/acne (72-84%), stomatitis (34-73%) with afatinib; and included stomatitis (39-100%), fatigue (22-50%), nausea (19-36%) with methotrexate.
|
31450171 |
2019 |
|
Vaginal Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
All 3 neoplasms were diffusely positive with p16 (block-type immunoreactivity) and the anal canal lesion contained high-risk human papillomavirus type 16; the 2 vaginal neoplasms underwent human papillomavirus testing but were unsuitable for analysis.
|
29257037 |
2019 |
|
Lichen Simplex Chronicus
|
0.010 |
Biomarker
|
disease |
BEFREE |
CVIN with superimposed LSC demonstrated intense p16 positivity extending from the basal cells to the mid-epithelium and a reduction or loss of staining in maturing keratinocytes.
|
29750709 |
2019 |
|
Malignant neoplasm of cheek mucosa
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The prevalence of HPV16 in Chinese OSCC patients was low. p16 overexpression decoupled from HPV infection was not a prognostic marker for OSCC patients except for patients with the buccal mucosa cancer.
|
31594213 |
2019 |
|
Portal Vein Thrombosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
FHIT was related to HCC tumor-node-metastasis (TNM) staging, the differentiation degree in Edmondson-Steiner grading, lymph node metastasis and portal vein thrombosis (P<0.05 in all comparisons), whereas, p16 was associated with tumor size and the differentiation degree in Edmondson-Steiner grading (P<0.05 in all comparisons).
|
30655841 |
2019 |
|
Adenosquamous carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
CK19 and BerEP4 were positive in BSC and focally in ASC but negative in CC. p16 was positive in 3 (60%) of the CCs, focally positive in ASC and negative in BSC.
|
31548087 |
2019 |
|
Carcinoma, Lobular
|
0.010 |
Biomarker
|
disease |
BEFREE |
Correlation of p16 Expression on Cancer and Stromal Cells With Clinicopathologic and Immunohistochemical Features of Lobular Breast Carcinoma.
|
31592814 |
2019 |
|
Epithelioid and spindle cell nevus
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Additional FISH analyses detected a 9p21/CDKN2A double deletion, frequently reported in melanomas but not in nevi, in the tumor initially diagnosed as a Spitz nevus with a favor malignant p16-Ki-67-HMB45 score.
|
28362709 |
2019 |