CDKN2A, cyclin dependent kinase inhibitor 2A, 1029

N. diseases: 1314; N. variants: 146
Disease: polyps ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0032584
Disease: polyps
polyps 		0.030 AlteredExpression phenotype BEFREE Up and downregulation of p16(Ink4a) expression in BRAF-mutated polyps/adenomas indicates a senescence barrier in the serrated route to colon cancer. 21423154 2011
CUI: C0032584
Disease: polyps
polyps 		0.030 Biomarker phenotype BEFREE None of the anal transition zone samples or fibroepithelial polyps showed Ki-67 or p16/CDKN2A staining. 20871219 2010
CUI: C0032584
Disease: polyps
polyps 		0.030 GeneticVariation phenotype BEFREE We investigated the frequency of promoter region CpG island methylation (CIM) of hMLH1, MGMT, MINT1, MINT2, and p16 and K-ras mutations in a total of 79 hyperplastic (serrated) polyps (HPs) from 75 patients and correlated the molecular profiles to polyp location in the colorectum, histologic variation, and other factors. 15087661 2004