CDKN2A, cyclin dependent kinase inhibitor 2A, 1029

N. diseases: 115; N. variants: 105
Disease: Malignant mesothelioma ×
Source: CURATED ×
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma 		0.400 Biomarker disease CTD_human Long-Fiber Carbon Nanotubes Replicate Asbestos-Induced Mesothelioma with Disruption of the Tumor Suppressor Gene Cdkn2a (Ink4a/Arf). 29112861 2017
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma 		0.400 Biomarker disease CTD_human Mice doubly deficient for Ink4a and Arf, due to deletion of Cdkn2a/Arf exon 2, showed accelerated asbestos-induced MM formation relative to mice deficient for Ink4a or Arf alone, and MMs exhibited biallelic loss of both tumor suppressor genes. 21526190 2011
CUI: C0345967
Disease: Malignant mesothelioma
Malignant mesothelioma 		0.400 Biomarker disease CTD_human Activated TNF-alpha/NF-kappaB signaling via down-regulation of Fas-associated factor 1 in asbestos-induced mesotheliomas from Arf knockout mice. 19223589 2009