|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Identification of MMTV-associated p14 proteins in benign breast tissues confirms prior PCR-based studies that MMTV infection occurs before the development of MMTV positive breast cancer.
|
29868468 |
2018 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Expression of ANRIL-Polycomb Complexes-CDKN2A/B/ARF Genes in Breast Tumors: Identification of a Two-Gene (EZH2/CBX7) Signature with Independent Prognostic Value.
|
27102007 |
2016 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
We conclude that YB-1 cooperates with p300 to allow BMI1 to over-ride p16(INK4a) -mediated cell cycle arrest enabling self-renewal and the development of aggressive breast tumors.
|
24648416 |
2014 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
In addition, p16(INK4A)-defective fibroblasts accelerated breast tumor xenograft formation and growth rate in mice.
|
22751126 |
2013 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
We showed that the methylation frequencies ranged from 19.6% (p16 ( INK4a )) to 87% (RASSF1A) in primary breast tumors of Tunisian patients.
|
19657672 |
2010 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
CTD_human |
RB-pathway disruption in breast cancer: differential association with disease subtypes, disease-specific prognosis and therapeutic response.
|
20948315 |
2010 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
LHGDN |
Frequent deletion and methylation in SH3GL2 and CDKN2A loci are associated with early- and late-onset breast carcinoma.
|
18239974 |
2008 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
LHGDN |
[Correlation of p16/INK4a gene damages and protein expression in the tumor tissue of sporadic breast cancer].
|
18807517 |
2008 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
LHGDN |
TBX3 is overexpressed in breast cancer and represses p14 ARF by interacting with histone deacetylases.
|
18245468 |
2008 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
LHGDN |
Low prevalence of CDKN2A/ARF mutations among early-onset cancers of breast, pancreas and malignant melanoma in Poland.
|
18714178 |
2008 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Breast tumors in women with the CDKN2A variant were more commonly intraductal cancers (DCIS) with micro-invasion (14.8% vs. 8.5%; P = 0.035).
|
17061045 |
2007 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
LHGDN |
Breast tumors in women with the CDKN2A variant were more commonly intraductal cancers (DCIS) with micro-invasion (14.8% vs. 8.5%; P = 0.035).
|
17061045 |
2007 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Expression of ANRIL mainly coclustered with p14/ARF both in physiologic (various normal human tissues) and in pathologic conditions (human breast tumors).
|
17440112 |
2007 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
LHGDN |
These results demonstrate a causal role of p16(INK4A) disruption in modulating DNA hypermethylation, and identify a dynamic and active process whereby epigenetic modulation of gene expression is activated as an early event in breast tumor progression.
|
16766534 |
2006 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
LHGDN |
A common variant of CDKN2A (p16) predisposes to breast cancer.
|
15879498 |
2005 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
LHGDN |
p53 activation in chronic radiation-treated breast cancer cells: regulation of MDM2/p14ARF.
|
14729628 |
2004 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
LHGDN |
Overexpression of p16INK4a correlates with high expression of p73 in breast carcinomas.
|
15450420 |
2004 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Finally, the results indicate that these proteins are often co-altered in primary breast tumours and that p16INK4a and p14ARF had non-independent behaviour, since they were silenced or overexpressed concomitantly with a significant correlation (p < 0.05).
|
12579530 |
2003 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
LHGDN |
Recombinant adenovirus-mediated p14(ARF) overexpression sensitizes human breast cancer cells to cisplatin.
|
12200117 |
2002 |
|
Mammary Neoplasms
|
0.500 |
AlteredExpression
|
group |
LHGDN |
[A study on homozygous deletion, hypermethylation, mutation and expression of p16 gene in human breast cancer].
|
11869517 |
1999 |
|
Mammary Neoplasms
|
0.500 |
PosttranslationalModification
|
group |
BEFREE |
These data suggest that DNA methylation of the p16 gene in some breast tumours could be the result of an active process that generates a discrete methylation pattern and, hence, could ultimately be amenable to therapeutic manipulation.
|
9888465 |
1999 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
BEFREE |
Recently, we reported loss of heterozygosity of the region in which p16(INK4a) is located in more than one-half of primary breast tumors.
|
9816158 |
1996 |
|
Mammary Neoplasms
|
0.500 |
GeneticVariation
|
group |
BEFREE |
Our results suggest that the MTS1 gene is not mutated with increased frequency in primary breast tumors, and thus may not play a major role in breast carcinogenesis.
|
7889533 |
1995 |
|
Mammary Neoplasms
|
0.500 |
Biomarker
|
group |
HPO |
|
|
|