|
Sotos' syndrome
|
0.300 |
GermlineCausalMutation
|
disease |
ORPHANET |
Thus, APC2 is a crucial target of NSD1, which provides an explanation for the intellectual disability associated with Sotos syndrome.
|
25753423 |
2015 |
|
Urogenital Abnormalities
|
0.300 |
Biomarker
|
group |
GENOMICS_ENGLAND |
Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
|
22573669 |
2012 |
|
Cardiovascular Abnormalities
|
0.300 |
Biomarker
|
group |
GENOMICS_ENGLAND |
Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
|
22573669 |
2012 |
|
Morphological abnormality of the central nervous system
|
0.300 |
Biomarker
|
group |
GENOMICS_ENGLAND |
Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
|
22573669 |
2012 |
|
Abnormality of the skeletal system
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
|
22573669 |
2012 |
|
Abnormality of nervous system morphology
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
|
22573669 |
2012 |
|
Hearing abnormality
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
|
22573669 |
2012 |
|
Abnormality of the eye
|
0.300 |
Biomarker
|
phenotype |
GENOMICS_ENGLAND |
Directional neuronal migration is impaired in mice lacking adenomatous polyposis coli 2.
|
22573669 |
2012 |
|
Colorectal Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Genomic and epigenomic integration identifies a prognostic signature in colon cancer.
|
21278247 |
2011 |
|
Colorectal Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis.
|
18507500 |
2008 |
|
Colorectal Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Epigenetic regulation of WNT signaling pathway genes in inflammatory bowel disease (IBD) associated neoplasia.
|
18716850 |
2008 |
|
Mammary Neoplasms, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis.
|
18507500 |
2008 |
|
Mammary Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis.
|
18507500 |
2008 |
|
Mammary Carcinoma, Human
|
0.300 |
Biomarker
|
disease |
CTD_human |
Convergence of mutation and epigenetic alterations identifies common genes in cancer that predict for poor prognosis.
|
18507500 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
For neoplastic mucosa a five marker panel (SFRP2, SFRP4, WIF1, APC1A, APC2) was accurate in detecting pre-cancerous and invasive neoplasia (AUC = 0.83; 95% CI: 0.79, 0.88), and dysplasia (AUC = 0.88; (0.84, 0.91).
|
30473377 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
APC2-deficiency in these mice resulted in predisposition to granulosa cell tumour (GCT) formation, accompanied by acute tumour-associated WNT-signalling activation and a histologic pattern and molecular signature seen in human adult GCTs.
|
31291912 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Hsa_circ_0009361 acted as a tumor suppressive sponge of miR-582, which could up-regulate the expression of APC2, inhibit the Wnt/β-catenin signaling, and suppress the growth and metastasis of CRC.
|
31109967 |
2019 |
|
Adenomatous Polyposis Coli
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, circ-PKD2 was identified as a sponge for miR-204-3p and upregulated the expression of adenomatous polyposis coli 2 (APC2), which was the functional target of miR-204-3p.
|
31206208 |
2019 |
|
Adenomatous Polyposis Coli
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of hsa_circ_0009361 up-regulated the expression of adenomatous polyposis coli 2 (APC2) and inhibited the activity of the Wnt/β-catenin pathway by competitively combining with miR-582.
|
31109967 |
2019 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
The roles of Adenomatous polyposis coli 2 (APC2), a little-studied WNT signalling pathway regulator, in ovarian homeostasis, fertility and tumourigenesis have not previously been explored.
|
31291912 |
2019 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
APC2 methylation was upregulated (43.93% vs 7.31%, <i>p</i> < 0.05) in tumors compared to adjacent FFPE tissues.
|
30510602 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We found miR-4326 targets tumor suppressor adenomatous polyposis coli 2 (APC2), which is a negative regulator of Wnt pathway, by binding to the 3'UTR of APC2.
|
29101731 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings demonstrate that overexpressed G9a represents a promising therapeutic target, and targeting G9a potentially suppresses growth and Wnt signaling pathway partially through down-regulating HP1α and epigenetically restoring these tumor suppressors such as APC2 that are silenced in NSCLC.
|
30348169 |
2018 |
|
Adenomatous Polyposis Coli
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
To investigate methylation of the adenomatosis polyposis coli homologue (APC2) promoter and its correlation with prognostic implications in Chinese colorectal cancer (CRC).
|
30510602 |
2018 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our work presented here supports a model that cortical localization of APC2 is governed in part by self-association through the N-terminal APC Self-Association Domain (ASAD) and a highly conserved coiled-coil within the C30 domain.
|
30019417 |
2018 |