|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
For neoplastic mucosa a five marker panel (SFRP2, SFRP4, WIF1, APC1A, APC2) was accurate in detecting pre-cancerous and invasive neoplasia (AUC = 0.83; 95% CI: 0.79, 0.88), and dysplasia (AUC = 0.88; (0.84, 0.91).
|
30473377 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
APC2-deficiency in these mice resulted in predisposition to granulosa cell tumour (GCT) formation, accompanied by acute tumour-associated WNT-signalling activation and a histologic pattern and molecular signature seen in human adult GCTs.
|
31291912 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Hsa_circ_0009361 acted as a tumor suppressive sponge of miR-582, which could up-regulate the expression of APC2, inhibit the Wnt/β-catenin signaling, and suppress the growth and metastasis of CRC.
|
31109967 |
2019 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
APC2 methylation was upregulated (43.93% vs 7.31%, <i>p</i> < 0.05) in tumors compared to adjacent FFPE tissues.
|
30510602 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We found miR-4326 targets tumor suppressor adenomatous polyposis coli 2 (APC2), which is a negative regulator of Wnt pathway, by binding to the 3'UTR of APC2.
|
29101731 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These findings demonstrate that overexpressed G9a represents a promising therapeutic target, and targeting G9a potentially suppresses growth and Wnt signaling pathway partially through down-regulating HP1α and epigenetically restoring these tumor suppressors such as APC2 that are silenced in NSCLC.
|
30348169 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The exact contribution of the Wnt-regulating proteins adenomatous polyposis coli (APC) and APC2 in the pathogenesis of human breast cancer are ill-defined, but our analysis of publically available array data sets indicates that tumors with concomitant low expression of both proteins occurs more frequently in the 'triple negative' phenotype, which is a subtype of breast cancer with particularly poor prognosis.
|
27694902 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Bioinformatics analysis further revealed APC2, a putative tumor suppressor as a potential target of miR-939.
|
25960217 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
APC-2 gene was methylated and down regulated in primary RB tumors.
|
25207834 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Our data suggest that the functional complementation of APCL by APC constitutes a substantial facet of tumour development, because the truncating mutations of APC in colorectal tumours from familial adenomatous polyposis (FAP) patients are almost always selected for the retention of at least one 15R.
|
23840886 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In the multivariate logistic regression model, methylation of APC1A and APC2 was more likely to be associated with IBD-associated neoplasia than IBD colitis.
|
18716850 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Analysis yielded 20 novel genes differentially expressed in both lung adenomas and ACs versus normal lungs, including the tumor suppressor APC2 and the oncogene Ros 1.
|
14647414 |
2004 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Interphase fluorescence in situ hybridization analysis revealed an APC2 allelic imbalance in 19 of 20 ovarian cancers screened and indicates that APC2 could be a potential tumor suppressor gene in ovarian cancer.
|
11691822 |
2001 |