|
Adenomatous Polyposis Coli
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In addition, circ-PKD2 was identified as a sponge for miR-204-3p and upregulated the expression of adenomatous polyposis coli 2 (APC2), which was the functional target of miR-204-3p.
|
31206208 |
2019 |
|
Adenomatous Polyposis Coli
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of hsa_circ_0009361 up-regulated the expression of adenomatous polyposis coli 2 (APC2) and inhibited the activity of the Wnt/β-catenin pathway by competitively combining with miR-582.
|
31109967 |
2019 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
The roles of Adenomatous polyposis coli 2 (APC2), a little-studied WNT signalling pathway regulator, in ovarian homeostasis, fertility and tumourigenesis have not previously been explored.
|
31291912 |
2019 |
|
Adenomatous Polyposis Coli
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
To investigate methylation of the adenomatosis polyposis coli homologue (APC2) promoter and its correlation with prognostic implications in Chinese colorectal cancer (CRC).
|
30510602 |
2018 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our work presented here supports a model that cortical localization of APC2 is governed in part by self-association through the N-terminal APC Self-Association Domain (ASAD) and a highly conserved coiled-coil within the C30 domain.
|
30019417 |
2018 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, we show that through its B-Box domains, Brat acts cell autonomously to regulate the expression and localization of Adenomatous polyposis coli-2 (Apc2), a key component of the Wnt canonical signaling pathway, to promote axon growth across the midline.
|
29617376 |
2018 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
We propose a model in which APC and APC2 function to promote β-catenin degradation, and APC also acts as a molecular "gatekeeper" to block receptor activation via the clathrin pathway.
|
29533772 |
2018 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
The exact contribution of the Wnt-regulating proteins adenomatous polyposis coli (APC) and APC2 in the pathogenesis of human breast cancer are ill-defined, but our analysis of publically available array data sets indicates that tumors with concomitant low expression of both proteins occurs more frequently in the 'triple negative' phenotype, which is a subtype of breast cancer with particularly poor prognosis.
|
27694902 |
2017 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
Therefore, it was speculated that adenomatous polyposis coli 2 (APC2) could play important roles in activating the Wnt/β-catenin pathway.
|
25960217 |
2015 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
Here we show that a novel N-terminal coil, the APC self-association domain (ASAD), found in vertebrate and invertebrate APCs, directly mediates self-association of Drosophila APC2 and plays an essential role in the assembly and stability of the destructosome that regulates β-cat degradation in Drosophila and human cells.
|
25208568 |
2014 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In addition, we generate an APC2 mutant lacking all β-catenin-binding sites (including the 15Rs) and find that a direct β-catenin/APC interaction is also not essential for β-catenin destruction, although it increases destruction complex efficiency in certain developmental contexts.
|
24931405 |
2014 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our data suggest that the functional complementation of APCL by APC constitutes a substantial facet of tumour development, because the truncating mutations of APC in colorectal tumours from familial adenomatous polyposis (FAP) patients are almost always selected for the retention of at least one 15R.
|
23840886 |
2013 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we directly tested APC's proposed roles in the nucleus or in precisely localizing the destruction complex by generating a series of APC2 variants to which we added tags relocalizing otherwise wild-type APC to different cytoplasmic locations.
|
22513088 |
2012 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Familial adenomatous polyposis in children younger than age ten years: a multidisciplinary clinic experience.
|
18157572 |
2008 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
APC2 remained associated with actin filaments after treatment with the actin-disrupting agent, cytochalasin D. These results suggest that APC2 is involved in actin-associated events and could influence cell motility or adhesion through interaction with actin filaments, as well as functioning independently or in cooperation with APC to down-regulate beta-catenin signaling.
|
11691822 |
2001 |
|
Adenomatous Polyposis Coli
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analysis of APCL, a brain-specific adenomatous polyposis coli homologue, for mutations and expression in brain tumors.
|
10551328 |
1999 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
APC and APC2 may therefore have comparable functions in development and cancer.
|
10021369 |
1999 |
|
Adenomatous Polyposis Coli
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that the APCL protein may be involved in the Wnt/Wingless signal pathway, and the identification of a novel relative of APC may provide new insights into the function of APC.
|
9823329 |
1998 |