|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this study, we verify the association between the rs1333049 single nucleotide polymorphism (9p21.3) within CDKN2A-CDKN2B and coronary artery disease (CAD) in an Italian population.
|
28639227 |
2017 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.
|
24262325 |
2014 |
|
Coronary Artery Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Interferon-γ activates expression of p15 and p16 regardless of 9p21.3 coronary artery disease risk genotype.
|
23199516 |
2013 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our thorough genomic characterization of 9p21.3 suggests common variants likely account for observed disease associations and provides further support for the hypothesis that complex regulatory variation affecting ANRIL and CDKN2B gene expression may contribute to increased risk for clinically apparent and subclinical coronary artery disease and aortic disease.
|
23315372 |
2013 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently, genome-wide association studies on coronary artery disease (CAD) identified a series of associated single-nucleotide polymorphisms (SNPs) in an intergenic region of chromosome 9p21.3, near the CDKN2A and CDKN2B genes.
|
23086272 |
2013 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
In 3 of the 14 regions, TCF7L2 (T2D), CTLA4 (Graves' disease) and CDKN2A-CDKN2B (T2D), much of the posterior probability rested on a single SNP, and, in 4 other regions (CDKN2A-CDKN2B (CAD) and CDKAL1, FTO and HHEX (T2D)), the 95% sets were small, thereby excluding most SNPs as potentially causal.
|
23104008 |
2012 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies have identified a coronary artery disease (CAD) risk locus in a non-coding region at 9p21.3, the nearest genes being CDKN2A and CDKN2B.
|
22768093 |
2012 |
|
Coronary Artery Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
The results of this study indicate that the 9p21 variation has an impact on CDKN2A and CDKN2B expression in VSMCs and influences VMSC proliferation, which likely represents an important mechanism for the association between this genetic locus and susceptibility to CAD.
|
22706276 |
2012 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
CTD_human |
In 3 of the 14 regions, TCF7L2 (T2D), CTLA4 (Graves' disease) and CDKN2A-CDKN2B (T2D), much of the posterior probability rested on a single SNP, and, in 4 other regions (CDKN2A-CDKN2B (CAD) and CDKAL1, FTO and HHEX (T2D)), the 95% sets were small, thereby excluding most SNPs as potentially causal.
|
23104008 |
2012 |
|
Coronary Artery Disease
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
Further investigation determined that p15(INK4b) hypermethylation prevalently emerged in lymphocytes of CAD patients (p = 0.013).
|
23091611 |
2012 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
This is the first report of a CAD association signal in a population of African ancestry with a common variant within the CDKN2B gene, independent from previous findings in European and East Asian ancestry populations.
|
21270820 |
2011 |
|
Coronary Artery Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Cardiac expression of two genes near the non-coding interval, Cdkn2a and Cdkn2b, is severely reduced in chr4(Delta70kb/Delta70kb) mice, indicating that distant-acting gene regulatory functions are located in the non-coding CAD risk interval.
|
20173736 |
2010 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Significantly reduced expression of all INK4/ARF transcripts (p15(INK4b), p16(INK4a), ARF and ANRIL) was found in PBTL of individuals harboring a common SNP (rs10757278) associated with increased risk of coronary artery disease, stroke and aortic aneurysm.
|
19343170 |
2009 |
|
Coronary Artery Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recently independent studies reported an association between coronary heart disease and single-nucleotide polymorphisms (SNPs) located at chromosome 9p21, near CDKN2A and CDKN2B genes.
|
18340101 |
2008 |
|
Glaucoma
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis indicates that CDKN2B gene rs1063192 polymorphism is significantly associated with a decreased risk of glaucoma.
|
28416752 |
2017 |
|
Glaucoma
|
0.450 |
Biomarker
|
disease |
BEFREE |
Many genome-wide association studies have identified common single nucleotide polymorphisms (SNPs) at the 9p21 glaucoma locus (CDKN2B/CDKN2B-AS1) to be significantly associated with primary open-angle glaucoma (POAG), with association being stronger in normal tension glaucoma (NTG) and advanced glaucoma.
|
27367510 |
2016 |
|
Glaucoma
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
Our study was unable to confirm previous associations reported for variants in CDKN2B-AS1, CDKN2B, and SIX1 with any type of glaucoma.
|
25489222 |
2014 |
|
Glaucoma
|
0.450 |
GeneticVariation
|
disease |
GWASDB |
Common variants on chromosome 9p21 are associated with normal tension glaucoma.
|
22792221 |
2012 |
|
Glaucoma
|
0.450 |
Biomarker
|
disease |
CTD_human |
We also show that CDKN2A and CDKN2B are upregulated in the retina of a rat model of glaucoma.
|
21532571 |
2011 |
|
Glaucoma
|
0.450 |
AlteredExpression
|
disease |
BEFREE |
We also show that CDKN2A and CDKN2B are upregulated in the retina of a rat model of glaucoma.
|
21532571 |
2011 |
|
Glaucoma
|
0.450 |
GeneticVariation
|
disease |
GWASDB |
We also show that CDKN2A and CDKN2B are upregulated in the retina of a rat model of glaucoma.
|
21532571 |
2011 |
|
Glaucoma
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, we found consistent evidence for three common variants (CDKN2B, ATOH7 and SIX1) significantly associated with glaucoma.
|
21427129 |
2011 |
|
MYELODYSPLASTIC SYNDROME
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
In addition, p15(INK4B) methylation was significantly higher in advanced MDS than in early MDS (OR, 4.70; P < .001) and was linked to an unfavorable overall survival (multivariate analysis: HR, 1.78; 95% CI, 1.23-2.71).
|
31023595 |
2019 |
|
Malignant Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Inhibition of S6K1 is able to resensitize PIK3CA<sup>E545K</sup>-expressing NRAS-mutant melanoma cells to MEKi + CDK4i.<i>Cancer Discov; 8(5); 556-67.
|
29496665 |
2018 |
|
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
CDKN2A/CDKN2B locus on 9p21 is reported to be associated with various diseases, including cancer and cardiovascular and inflammatory diseases.
|
29063720 |
2018 |