|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We analyzed 22 patients with CIS of the bladder (15 patients with isolated CIS, 7 patients combined with synchronous pTa or pT1 carcinomas) for gains and losses of chromosome (peri)centromere loci 1q12, 7p11-q11, 9p11-q12, and 9p21 harboring the INK4A/ARF locus (p16(INK4A)/p14(ARF)) and INK4B (p15(INK4B)) by multiple-target fluorescence in situ hybridization, and for p53 protein accumulation by immunohistochemistry.
|
12368185 |
2002 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Molecular analysis of the INK4A and INK4B gene loci in human breast cancer cell lines and primary carcinomas.
|
11369056 |
2001 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
p15(INK4b) in bladder carcinomas: decreased expression in superficial tumours.
|
11720438 |
2001 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
As PCR based approaches analyzing for homozygous deletions could be confounded by unavoidable contributions of normal cells in microdissected tissue, we performed in situ hybridization (ISH) on primary prostate carcinomas to accurately evaluate p16 and p15 copy numbers on a cell-by-cell basis.
|
11025389 |
2000 |
|
Carcinoma
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results indicate that disregulation of p16MTS1/CDK4I protein and mRNA expression is a frequent phenomenon in laryngeal carcinomas commonly associated with gene alterations and 9p21 LOH.
|
10328220 |
1999 |
|
Carcinoma
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
To determine the frequency of deletions and point mutations of these genes in human cervical cancer, we examined for alterations of the p15INK4B and p16INK4A genes in cervical carcinomas.
|
9698478 |
1998 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
All p16MTS1/CDK4I mutated cases and the two hypermethylated carcinomas showed 9p21-23 loss of heterozygosity.
|
9333020 |
1997 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Deletions or mutations of the p16 and p15 genes are uncommon in primary gastric carcinomas.
|
9366289 |
1997 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Homozygous deletions of p16INK4 were detected in 7 of 128 (5%) cervical, 1 of 41 (2%) endometrial, 2 of 27 (7%) ovarian, and 3 of 6 (50%) vulvar carcinomas, while homozygous deletions of p15INK4B were detected in 19 of 128 (15%) cervical, 1 of 41 (2%) endometrial, 9 of 27 (33%) ovarian, and 3 of 6 (50%) vulvar carcinomas, respectively.
|
9159345 |
1997 |
|
Carcinoma
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The multiple tumor suppressor 1 (MTS1) and 2 (MTS2) genes, located on chromosome 9p21, have been reported to be deleted or mutated in many malignant cell lines and in a high percentage of some primary carcinomas.
|
8957063 |
1996 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Seven of 9 alterations in p16/CDKN2 and p15/MTS2 were observed in serous (3 of 12), endometrioid (3 of 9) and clear-cell (1 of 4) carcinomas.
|
8980248 |
1996 |
|
Carcinoma
|
0.100 |
Biomarker
|
group |
BEFREE |
Deletion of p16INK4a and/or p15INK4b was seen in 8 of 10 cell lines derived from spindle carcinomas, the most advanced stage of skin carcinogenesis.
|
7585567 |
1995 |