CDKN2B, cyclin dependent kinase inhibitor 2B, 1030

N. diseases: 440; N. variants: 13
Disease: Acute leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 Biomarker disease BEFREE Prognostic impact of p15 gene aberrations in acute leukemia. 27401303 2017
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 PosttranslationalModification disease BEFREE To the best of our knowledge, this is the first report showing the possible association between P15(INK4B) promoter methylation and parvovirus B19 infection in acute leukemia. 18384396 2009
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 PosttranslationalModification disease BEFREE Cyclin-dependent kinase inhibitor p15 is frequently inactivated by either methylation or deletion in patients with acute leukemia. 15755508 2005
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 GeneticVariation disease BEFREE Hypermethylation of CpG islands in the promoter region of the p15INK4B gene in childhood acute leukaemia. 15737564 2005
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 PosttranslationalModification disease BEFREE The frequency of p15(INK4B) gene methylation in newly diagnosed or relapsed AL was significantly higher than that in AL in the remission stage (P = 0.002) p15(INK4B) gene methylation was found in 5 of 13 (38%) low-risk MDS (RA/RAS) patients and 80% of them showed only partial methylation. 12150726 2002
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 PosttranslationalModification disease BEFREE In this study, the authors investigated the frequency and prognostic significance of p15 and p16 gene methylation in adult acute leukemia. 11413509 2001
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 PosttranslationalModification disease BEFREE Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications. 10706859 2000
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 Biomarker disease BEFREE These results suggest that inactivation of p16 and p15 genes is one of the most common genetic events in acute leukemia, and plays an important role for the RB/p16 pathway in the pathogenesis of acute leukemia. 10634644 2000
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 GeneticVariation disease BEFREE Reports on homozygous deletion of p16 and p15 genes suggest the value of larger, prospective studies with standardized treatment protocols to definitively establish the prognostic utility of p15/p16 deletions in acute leukemias. 10073286 1999
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 PosttranslationalModification disease BEFREE The entire CpG island region of p15 was largely devoid of methylation in normal lymphocytes, but methylation of varying density was found in primary acute leukemia. 10498617 1999
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 GeneticVariation disease BEFREE Our results suggest that alterations of p16 and p15 genes are involved in a subset of acute leukemias with MLL gene rearrangement not only of lymphoid but also of myeloid phenotype. 9447829 1997
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 GeneticVariation disease BEFREE These data show that inactivation of either the p15 or p16 gene by point mutation is a very uncommon event in acute leukaemias. 8616035 1996
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.100 GeneticVariation disease BEFREE These results demonstrate that CDK4I gene deletions are very frequent and probably early events in childhood acute leukaemias of lymphoid origin and especially in early-T and pre-B ALLs. 8555068 1995