MYELODYSPLASTIC SYNDROME
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
In addition, p15(INK4B) methylation was significantly higher in advanced MDS than in early MDS (OR, 4.70; P < .001) and was linked to an unfavorable overall survival (multivariate analysis: HR, 1.78; 95% CI, 1.23-2.71).
|
31023595 |
2019 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
On the contrary, methylation of the p15 promoter is identified in some 50% of the patients with AML and MDS, but is less frequent in ALL.
|
27401303 |
2017 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
We confirmed that methylation of CDKN2B is associated with the pathogenesis and prognosis in pediatric MDS.
|
23571652 |
2013 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
Biomarker
|
group |
BEFREE |
However, animal model experiments over the last several years have produced a very different picture of how p15Ink4b functions in hematopoietic cells and how its loss contributes to myelodysplastic syndrome and myeloid leukemia.
|
23403260 |
2013 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Aberrant methylation was present in the CDKN2A gene in 38% and in the CDKN2B gene in 77% of the patients in MDS group.
|
22248274 |
2012 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The re-expression of p15 in PC-MDS cell line evaluated by qRT-PCR makes this novel cell line a suitable model for the studies of pharmacologic demethylation as a plausible mechanism resulting in hematologic response in myelodysplastic syndrome (MDS).
|
21674861 |
2011 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Epigenetic alterations of p15(INK4B) and p16(INK4A) genes in pediatric primary myelodysplastic syndrome.
|
20658957 |
2010 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Recent exciting data suggest that methylation of p15 INK4b and of CTNNA1 (in 5q-), high level of methylation of other genes, absence of the TET2 mutation, down regulation of the lymphoid enhancer binding factor 1 (LEF1), mutation of the polycomb-associated gene ASXL1 and a specific 6-gene signature in gene expression profiling - are all associated with poor prognosis in MDS.
|
20573398 |
2010 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Heavy p15INK4b methylation in MDS is associated with IPSS predictors of poor prognosis and adverse survival.
|
19782398 |
2010 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
In this study, we examined the P15(INK4B) gene promoter methylation in patients with myelodysplastic syndrome and acute leukemia and its possible relationship with parvovirus B19 and Epstein-Barr virus infections.
|
18384396 |
2009 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
Biomarker
|
group |
CTD_human |
P15INK4B gene hypermethylation is closely associated with MDS pathogenesis.
|
17294728 |
2007 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Extensive statistical analyses of the whole CpG island revealed for the first time disease-specific methylation patterns of the CDKN2B gene in myeloid malignancies and small regions of differential methylation with high discriminatory power that enabled differentiation of even low-grade myelodysplastic syndrome samples from the controls, a result that was confirmed in an independent group of 9 control and 36 patient samples.
|
17095538 |
2007 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Our findings indicate that CALCA and CDKN2B are frequently methylated in pediatric MDS.
|
16890288 |
2007 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Our findings indicate that CALCA and CDKN2B are frequently methylated in pediatric MDS.
|
16890288 |
2007 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
Biomarker
|
group |
BEFREE |
Since the function of cell cycle control genes including the cyclin-dependent kinase inhibitors known as p15(INK4b) and p16(INK4a), as well as p14(ARF) which blocks MDM-2 (an inhibitor of p53), the retinoblastoma (RB1) protein and the mismatch repair gene MGMT is critical for hematopoietic proliferation and differentiation, we performed methylation specific polymerase chain reaction (MSP) in low-density, non-adherent bone marrow cells from 49 patients with MDS.
|
16682076 |
2006 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Concurrent hypermethylation of > or = 3 genes was more frequent in advanced compared with early-stage MDS (P < or = 0.05), and hypermethylation of p15INK4B was associated with leukemic transformation in early MDS (P < or = 0.05).
|
16343268 |
2006 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
The frequency of p15 hypermethylation in paediatric MDS was 78% (7/9), which was comparable to that in adult MDS.
|
15755284 |
2005 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
Biomarker
|
group |
BEFREE |
Although FHIT and p15(INK4B) methylations were not correlated in MDS and AML, increased FHIT methylation at the relapse in AML was associated with p15(INK4B) methylation.
|
15902282 |
2005 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Hypermethylation of p15(INK4b) in MDS is reversed during treatment with decitabine, resulting in reactivation of this gene.
|
16292549 |
2005 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
Biomarker
|
group |
BEFREE |
Progression of diseases such as MDS to secondary AML occur as a result of changes in the balance between cell proliferation and apoptosis and we will review targets in both these areas, including reversal of epigenetic silencing of genes such as p15(INK4B).
|
14757535 |
2004 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
Biomarker
|
group |
BEFREE |
The important cell cycle regulatory gene p15(INK4b) has been shown to be inactivated in acute myeloid leukemia and myelodysplastic syndrome.
|
12750705 |
2003 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
Biomarker
|
group |
BEFREE |
Nevertheless, some genes like p15INK4B in myelodysplastic syndrome (MDS) and p16INK4A in some lung cancer subtypes have been shown to confer a certain prognosis.
|
12930158 |
2003 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia.
|
12970781 |
2003 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The emergence of partially demethylated epigenotypes and re-establishment of normal p15 protein expression following the initial decitabine courses implicate pharmacologic demethylation as a possible mechanism resulting in hematologic response in MDS.
|
12351408 |
2002 |
MYELODYSPLASTIC SYNDROME
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Hypermethylation of the p15(INK4B) gene occurs frequently in leukemia and high-risk MDS.
|
12150726 |
2002 |