|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our study, the first to characterize the landscape of genomic rearrangements and copy number alterations of BPDCN at nucleotide-level resolution, revealed that IKZF1, a gene encoding a transcription factor required for the differentiation of plasmacytoid dendritic cell precursors, is focally inactivated through recurrent structural alterations in this neoplasm.
|
31846142 |
2020 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
By leveraging regulatory networks we previously characterized in autoimmunity, here we show that overexpression of the master regulator IKZF1 leads to enhanced immune infiltrate recruitment and tumor sensitivity to PD1 and CTLA4 inhibitors in several tumors that normally lack IKZF1 expression.
|
29960886 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We performed integrated genome-wide chromatin and expression analyses and identified Ikaros target genes in mouse and human BCR-ABL1<sup>+</sup> pre-B ALL, revealing novel conserved gene pathways associated with Ikaros tumor suppressor function.
|
28190001 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Ikaros (IKZF1) functions as a master regulator of hematopoiesis and a tumor suppressor in acute lymphoblastic leukemia (ALL).
|
26912004 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
IKAROS family zinc finger 1/IKZF1 is a transcription factor important in lymphoid differentiation, and a known tumor suppressor in acute lymphoid leukemia.
|
26069293 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Ikaros (IKZF1) is a tumor suppressor that binds DNA and regulates expression of its target genes.
|
26219304 |
2015 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thus, wild-type IKAROS restrains stemness properties and has tumor suppressor activity in BCR-ABL1-initiated leukemia.
|
24791856 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This review summarizes the role of Ikaros (IKZF1) in tumor suppression and regulation of gene expression in leukemia.
|
24659638 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study was attempted to determine the gene expression profiles of transcription factors (Tpit, NeuroD1 and IKZF1), proprotein convertase (PC) 1/3 and PC2, and several key receptors linked to ACTH secretion, including corticotrophin releasing hormone receptor (CRHR1), vasopressin receptor 1b (V1bR), somatostatin receptor (SSTR) subtype-2, -5 and dopamine receptor type 2 (D2R) in non-pituitary and pituitary ACTH-secreting tumors.
|
21383526 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, these miRNAs produce overlapping and cooperative effects on tumor suppressor genes implicated in the pathogenesis of T-ALL, including IKAROS (also known as IKZF1), PTEN, BIM, PHF6, NF1 and FBXW7.
|
21642990 |
2011 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The Ikaros (Ikzf1) gene, encoding a transcription regulator, is a major tumor suppressor in B-cell acute lymphoblastic leukemia (B-ALL).
|
19796813 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
IKAROS also promotes tumor suppression through cooperation with downstream molecules of the pre-B cell receptor signaling pathway, even if expression of the pre-B cell receptor itself is compromised.
|
19620627 |
2009 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Deletions of the CDKN2A/B tumor suppressor locus and of the IKAROS and PAX5 genes that promote B-lineage development occur frequently in lymphoid, but not myeloid leukemias initiated by the BCR-ABL tyrosine kinase.
|
18519632 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Gene targeting studies in mice have shown that the lack of Ikaros activity leads to T-cell hyperproliferation and T-cell neoplasia, establishing the Ikaros gene as a tumor suppressor gene in mice.
|
10463586 |
1999 |