|
Colorectal Carcinoma
|
0.350 |
Biomarker
|
disease |
CTD_human |
Discovery of common and rare genetic risk variants for colorectal cancer.
|
30510241 |
2019 |
|
Colorectal Carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
A Novel lncRNA, LINC00460, Affects Cell Proliferation and Apoptosis by Regulating KLF2 and CUL4A Expression in Colorectal Cancer.
|
30092404 |
2018 |
|
Colorectal Carcinoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
Rescue assays were used to determine whether P57 and Kruppel-like factor 2 (KLF2) were involved in SH3PXD2A-ASl-dependent CRC proliferation.
|
29734178 |
2018 |
|
Colorectal Carcinoma
|
0.350 |
Biomarker
|
disease |
BEFREE |
Collectively, we demonstrated that KLF2 mediates CRC cell biological processes including cell growth and apoptosis via regulating the HIF-1α/Notch-1 signal pathway.
|
28628187 |
2017 |
|
Colorectal Carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
Long noncoding RNA HOXA-AS2 represses P21 and KLF2 expression transcription by binding with EZH2, LSD1 in colorectal cancer.
|
28112720 |
2017 |
|
Colorectal Carcinoma
|
0.350 |
AlteredExpression
|
disease |
BEFREE |
A novel lncRNA, LL22NC03-N64E9.1, represses KLF2 transcription through binding with EZH2 in colorectal cancer.
|
28938648 |
2017 |
|
Colorectal Neoplasms
|
0.300 |
Biomarker
|
group |
CTD_human |
Discovery of common and rare genetic risk variants for colorectal cancer.
|
30510241 |
2019 |
|
Lung diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Down-regulation of lung Kruppel-like factor in the nitrofen-induced hypoplastic lung.
|
21053160 |
2011 |
|
Multiple Myeloma
|
0.110 |
GeneticVariation
|
disease |
GWASCAT |
Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma.
|
30213928 |
2018 |
|
Multiple Myeloma
|
0.110 |
Biomarker
|
disease |
BEFREE |
Our results indicate that the KDM3A-KLF2-IRF4 pathway plays an essential role in MM cell survival and homing to the bone marrow, and therefore represents a therapeutic target.
|
26728187 |
2016 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Low-dose phloretin helped with lipid metabolism, and blocked the acceleration of atherosclerosis in STZ-induced diabetic mice since the early stage, which was diminished by KLF2 knockdown.
|
31791197 |
2020 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Low-dose phloretin helped with lipid metabolism, and blocked the acceleration of atherosclerosis in STZ-induced diabetic mice since the early stage, which was diminished by KLF2 knockdown.
|
31791197 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The overexpression of KLF2 inhibited the migration and invasion of PCa cells via the suppression of MMP2.This study demonstrates that KLF2 might act as a tumor suppressor gene in PCa and that the pharmaceutical upregulation of KLF2 may be a potential approach for treatment.
|
30520325 |
2020 |
|
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MANTIS is tightly regulated by the transcription factors KLF2 and KLF4 and limits the ICAM-1 mediated monocyte adhesion to endothelial cells and thus potentially atherosclerosis development in humans.
|
31222221 |
2019 |
|
Arteriosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Simvastatin upregulated the reduced expression of Klf2 and Foxp1 in atherosusceptible vascular endothelium and alleviated vascular inflammation contributing to its inhibitory effect in atherosclerosis.
|
31318658 |
2019 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The KLF2 and NF-<i>κ</i>B may be potential therapeutic targets for interventions of inflammation associated with atherosclerosis.
|
30881601 |
2019 |
|
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Simvastatin upregulated the reduced expression of Klf2 and Foxp1 in atherosusceptible vascular endothelium and alleviated vascular inflammation contributing to its inhibitory effect in atherosclerosis.
|
31318658 |
2019 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The KLF2 and NF-<i>κ</i>B may be potential therapeutic targets for interventions of inflammation associated with atherosclerosis.
|
30881601 |
2019 |
|
Atherosclerosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
MANTIS is tightly regulated by the transcription factors KLF2 and KLF4 and limits the ICAM-1 mediated monocyte adhesion to endothelial cells and thus potentially atherosclerosis development in humans.
|
31222221 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Krüppel-like factor 2 (KLF2) is a member of the zinc finger family, which is considered a potential tumor suppressor gene due to its reduced expression in gastric cancer.
|
31497207 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Mechanistically, DUXAP8 repressed tumor suppressor KLF2 transcription through interacting with histone-lysine N-methyltransferase enzyme enhancer of zeste homolog 2.
|
31571902 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thus, we propose that the up-regulation of CNOT3 facilitates the development of non-small cell lung cancer through down-regulation of Krüppel-like factor 2 and p21, contrary to tumor suppressive functions of CNOT3 in T-ALL.
|
30531840 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The results showed that KLF2 might be a tumor suppressor gene in colon cancer, which was in accordance with our experimental data.
|
30833076 |
2019 |
|
Arteriosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study demonstrates the characteristic impact of EVs from ox-LDL-treated and/or KLF2-transduced ECs on the monocyte/macrophage phenotype in vitro and in vivo.Q-PCR showed that both the atherosclerosis inducer ox-LDL and atheroprotective factor KLF2 regulated inflammation-associated microRNA-155 (miR-155) expression in human umbilical vein endothelial cells (HUVECs).
|
29465752 |
2018 |
|
Atherosclerosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study demonstrates the characteristic impact of EVs from ox-LDL-treated and/or KLF2-transduced ECs on the monocyte/macrophage phenotype in vitro and in vivo.Q-PCR showed that both the atherosclerosis inducer ox-LDL and atheroprotective factor KLF2 regulated inflammation-associated microRNA-155 (miR-155) expression in human umbilical vein endothelial cells (HUVECs).
|
29465752 |
2018 |