KLF2, Kruppel like factor 2, 10365

N. diseases: 132; N. variants: 3
Disease: Coronary heart disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.030 Biomarker disease BEFREE <b>Conclusion:</b> Our findings suggest that the miR-25/KLF2 axis may be a potential therapeutic target for <i>H. pylori</i>-associated CHD. 31750260 2019
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.030 GeneticVariation disease BEFREE In a cohort of 1066 angiographic cases and 1011 controls, homozygous carriers of a deletion polymorphism (rs3045215) in the 3' untranslated region sequence of human IRF2BP2 mRNA had a higher risk of coronary artery disease (recessive model, odds ratio [95% confidence interval]=1.560 [1.179-2.065], P=1.73E-03) and had lower IRF2BP2 (and Krüppel-like factor 2) protein levels in peripheral blood mononuclear cells. 26195219 2015
CUI: C0010068
Disease: Coronary heart disease
Coronary heart disease 		0.030 AlteredExpression disease BEFREE Consistent with this observation, KLF2 expression in circulating monocytes is reduced in patients with chronic inflammatory conditions such as coronary artery disease. 16617118 2006