|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The overexpression of KLF2 inhibited the migration and invasion of PCa cells via the suppression of MMP2.This study demonstrates that KLF2 might act as a tumor suppressor gene in PCa and that the pharmaceutical upregulation of KLF2 may be a potential approach for treatment.
|
30520325 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Krüppel-like factor 2 (KLF2) is a member of the zinc finger family, which is considered a potential tumor suppressor gene due to its reduced expression in gastric cancer.
|
31497207 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Mechanistically, DUXAP8 repressed tumor suppressor KLF2 transcription through interacting with histone-lysine N-methyltransferase enzyme enhancer of zeste homolog 2.
|
31571902 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thus, we propose that the up-regulation of CNOT3 facilitates the development of non-small cell lung cancer through down-regulation of Krüppel-like factor 2 and p21, contrary to tumor suppressive functions of CNOT3 in T-ALL.
|
30531840 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The results showed that KLF2 might be a tumor suppressor gene in colon cancer, which was in accordance with our experimental data.
|
30833076 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Notably, KLF2 is considered a tumor suppressor gene in a variety of tumors.
|
30106140 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Mechanistic analyses indicated that DUXAP8 regulates PC cell proliferation partly through downregulation of tumor suppressor CDKN1A and KLF2 expression.
|
30367681 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mechanistic investigation reveals that tumor suppressor KLF2 is a key downstream target of lysine-specific demethylase-1 in gastric cancer.
|
28381185 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, our findings indicate that KLF2 may function as a tumor suppressor involved in the progression of human GC.
|
27655487 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Potentiation of treatment efficacy against colon cancer of dopamine via elevating KLF2 expression in tumor vascular endothelial cells.
|
29164576 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The transcription factor Krüppel-like factor 2 (KLF2) has been shown to function as a tumor suppressor and regulate biological processes of cancer cells, such as cell growth, cell apoptosis and angiogenesis.
|
28628187 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Impaired expression of KLF2 markedly promoted cell growth <i>in vitro</i> and significantly expanded tumor size <i>in vivo</i>.
|
29245984 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, KLF2 possesses tumor suppressor functions in NSCLC and detection of KLF2 methylation should be further evaluated as a tumor or prognostic biomarker for NSCLC.
|
28469808 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Further mechanism study showed that, by binding to histone demethylase lysine-specific demethylase 1 (LSD1), an enhancer of zeste homolog 2 (EZH2), IRAIN reduced PC tumor cell apoptosis and induced growth arrest by silencing the expression of Kruppel-like factor 2 (KLF2) and P15.
|
27644252 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The data thus reveal that KLF2 suppresses tumor growth by controlling the transcriptional activities of RA.
|
26416422 |
2015 |