KLF2, Kruppel like factor 2, 10365

N. diseases: 132; N. variants: 3
Disease: Splenic Marginal Zone B-Cell Lymphoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0349632
Disease: Splenic Marginal Zone B-Cell Lymphoma
Splenic Marginal Zone B-Cell Lymphoma 		0.030 Biomarker disease BEFREE SMZL lymphomagenesis involves antigen and/or superantigen stimulation and molecular deregulation of genes (NOTCH2 and KLF2) involved in the physiological differentiation of spleen marginal zone B cells. 26989207 2016
CUI: C0349632
Disease: Splenic Marginal Zone B-Cell Lymphoma
Splenic Marginal Zone B-Cell Lymphoma 		0.030 GeneticVariation disease BEFREE We identified recurrent mutations in TP53 (16%), KLF2 (12%), NOTCH2 (10%), TNFAIP3 (7%), MLL2 (11%), MYD88 (7%), and ARID1A (6%), all genes known to be targeted by somatic mutation in SMZL. 25779943 2015
CUI: C0349632
Disease: Splenic Marginal Zone B-Cell Lymphoma
Splenic Marginal Zone B-Cell Lymphoma 		0.030 GeneticVariation disease BEFREE Taken together, KLF2 mutation is the most common genetic change in SMZL and identifies a subset with a distinct genotype characterised by multi-genetic changes. 25428260 2015