KLF2, Kruppel like factor 2, 10365

N. diseases: 132; N. variants: 3
Disease: Ischemic stroke ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke 		0.030 Biomarker disease BEFREE Here, we investigated whether UA treatment after ischaemic stroke protects brain endothelial cell functions and modulates the KLF2-VEGF-A axis. 30954486 2019
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke 		0.030 GeneticVariation disease BEFREE ChIP-PCR and luciferase assays show that CAD/IS-protective allele at rs17114036 creates a binding site for transcription factor Krüppel-like factor 2 (KLF2), which increases the enhancer activity under unidirectional flow. 30429326 2018
CUI: C0948008
Disease: Ischemic stroke
Ischemic stroke 		0.030 Biomarker disease BEFREE In contrast, KLF2(tg) mice were protected against ischemic stroke and demonstrated preserved BBB function. 23335794 2013