|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC-1 may be a tumor suppressor gene in liver cancer as well as in other cancers.
|
9605766 |
1998 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The delineation of the gene structure allows mutation analysis of DLC1 in other tumour types for which it remains a candidate tumour suppressor gene based on its location and homology to rhoGAP.
|
10649492 |
2000 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC-1 (deleted in liver cancer 1) is a candidate tumor suppressor gene for hepatocellular carcinoma and other cancers.
|
12034501 |
2002 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC2 is homologous to DLC1, a previously identified tumor suppressor gene at 8p22-p21.3 frequently deleted in HCC.
|
12531887 |
2003 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Furthermore, introduction of the DLC-1 cDNA abolished the in vivo tumorigenicity in nude mice, suggesting that the DLC-1 gene plays a role in breast cancer by acting as a bona fide tumor suppressor gene.
|
12545165 |
2003 |
|
Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
To determine whether aberrant methylation is a contributing factor to transcriptional inactivation of DLC-1 (deleted in liver cancer-1), a candidate tumor suppressor gene, we examined its methylation status in twelve hepatocellular carcinoma. breast, colon, and prostate tumor cell lines with low or undetectable expression of DLC-1.
|
12645648 |
2003 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The DLC-1 gene, located on 8p21-p22, might be a candidate tumor suppressor gene in this region.
|
12759748 |
2003 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
While the pathogenic relevance of the intronic polymorphism is not known, the low rate of mutation of the DLC-1 gene in HCC implies that genomic deletion and promoter methylation primarily account for the altered expression and tumor suppressive inactivation of the DLC-1 gene.
|
12792785 |
2003 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC1 (deleted in liver cancer), a gene in this interval, has been proposed as a candidate tumor suppressor gene because of its homology (86% similarity) with rat p122 RhoGAP, which catalyzes the conversion of active GTP-bound rho complex to the inactive GDP-bound form, and thus suppresses Ras-mediated oncogenic transformation.
|
12873722 |
2003 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The results show that Dlc-1protein is localized in the cell cytoplasm, and the restoration of DLC-1 expression in HCC cells resulted in caspase-3-mediated apoptosis, inhibition of cell growth and invasiveness in vitro as well as in reduction of the ability of the cells to form tumors in athymic nude mice.
|
14647417 |
2004 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas.
|
14661059 |
2004 |
|
Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
In order to determine whether inactivation of DLC1 is involved in HNSCC, we have screened tumour cell lines for DLC1 mutations and expression.
|
15159023 |
2004 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Absence or low expression of DLC-1, a tumor suppressor gene, in breast cancers has been shown recently.
|
15201975 |
2004 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The aim of this study was to evaluate whether DLC-1, a newly identified tumor-suppressor gene on chromosome 8p22, is involved in the tumorigenesis of MBs and the histologically similar SPNETs.
|
15712180 |
2005 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Deleted in liver cancer-1 (DLC-1) is a tumour suppressor gene that is inactive in liver carcinogenesis.
|
16489177 |
2006 |
|
Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The deleted in liver cancer-1 (DLC-1) gene that encodes a Rho GTPase-activating protein with tumor suppressor function is located on chromosome 8p21-22, a region frequently deleted in prostate carcinomas.
|
16533763 |
2006 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Taken together, our results suggest that DLC-1 might be an NPC-related tumor suppressor gene affected by aberrant promoter methylation and gene deletion.
|
16680376 |
2006 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The methylation of the candidate tumor suppressor gene DLC-1 was detected in a high proportion of primary tumor and plasma DNA samples by using quantitative methylation-specific PCR analysis.
|
16774933 |
2007 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC1 appears to be a major TSG implicated in the pathogenesis of these tumors, and should be further tested as a molecular biomarker in patients with these cancers.
|
16862168 |
2007 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Interaction of deleted in liver cancer 1 with tensin2 in caveolae and implications in tumor suppression.
|
16951145 |
2006 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
This comparative expression analysis of DLC-1 and -2 identifies down-regulation of the two emerging bona fide tumor suppressor genes in additional types of solid tumors.
|
17016643 |
2006 |
|
Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
Aberrant DLC1 methylation appeared to be a relatively early event during renal tumorigenesis since 33% of the RCC tumors with pT1 (TNM staging) showed methylation, which is similar to other late stage tumors.
|
17029774 |
2007 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC-1 (deleted in liver cancer-1) is a tumor suppressor gene for hepatocellular carcinoma and other cancers.
|
17292327 |
2007 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Two related Rho GTPase-activating proteins, DLC-1 (deleted in liver cancer 1) and DLC-2, are emerging as bona fide tumor suppressor genes that inhibit cancer cell growth.
|
17297465 |
2007 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
More than a 10-fold increase in mRNA expression was observed for two previously identified tumor suppressor genes (DLC-1 and DCC) and also for RPIB9 and PCDHGA12.
|
17363581 |
2007 |