Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Tumor-specific methylation of the 8p22 tumor suppressor gene DLC1 is an epigenetic biomarker for Hodgkin, nasal NK/T-cell and other types of lymphomas.
|
17965626 |
2008 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Tumor suppressor gene DLC1 is shown to induce apoptosis, suppress migration and invasion in various cancer cells.
|
29964052 |
2018 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC-1 (deleted in liver cancer 1) is a candidate tumor suppressor gene for hepatocellular carcinoma and other cancers.
|
12034501 |
2002 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC1 (deleted in liver cancer), a gene in this interval, has been proposed as a candidate tumor suppressor gene because of its homology (86% similarity) with rat p122 RhoGAP, which catalyzes the conversion of active GTP-bound rho complex to the inactive GDP-bound form, and thus suppresses Ras-mediated oncogenic transformation.
|
12873722 |
2003 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC-1 operates as a tumor suppressor gene in human non-small cell lung carcinomas.
|
14661059 |
2004 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Deleted in liver cancer-1 (DLC-1) is a tumour suppressor gene that is inactive in liver carcinogenesis.
|
16489177 |
2006 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC1 appears to be a major TSG implicated in the pathogenesis of these tumors, and should be further tested as a molecular biomarker in patients with these cancers.
|
16862168 |
2007 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC-1 (deleted in liver cancer-1) is a tumor suppressor gene for hepatocellular carcinoma and other cancers.
|
17292327 |
2007 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC-1 that encodes a Rho GTPase-activating protein, functions as a tumor suppressor gene and is frequently inactivated or down-regulated in several common cancers.
|
17418982 |
2007 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC-1 is a multi-domain protein that includes a Rho GTPase activating protein (RhoGAP) domain which has been hypothesized to be the basis of its tumor suppressive actions.
|
17932950 |
2008 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC-1 (deleted in liver cancer-1) is a potential tumor suppressor gene, which is inactive in liver carcinogenesis.
|
18288400 |
2008 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Deleted in liver cancer-1 (DLC-1), encoding a Rho GTPase-activating protein (GAP), is considered as a promising candidate tumor suppressor gene in nasopharyngeal carcinoma (NPC).
|
18627284 |
2008 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Deleted in liver cancer 1 (DLC1), a tumor suppressor gene identified in a primary human hepatocellular carcinoma, encodes a Rho GTPase-activating protein (RhoGAP).
|
21130076 |
2011 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC-1 is a tumor suppressor gene frequently silenced in human cancers.
|
23509688 |
2013 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC-1 inhibits cell growth and invasion in human colon cancer, functioning as a tumor-suppressor gene, possibly through the regulation of the Wnt/β-catenin signaling pathway.
|
24604602 |
2014 |
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
DLC-1 expression was not found to be associated with tumor differentiation status.
|
26514520 |
2015 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Deleted in liver cancer 1 (DLC1) on chromosome 8p22, is an important tumor suppressor gene originally identified to be deleted in hepatocellular carcinoma.
|
26986853 |
2016 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC-1 has been identified as a candidate tumor suppressor.
|
27366946 |
2016 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC1 is a RhoGAP-containing tumor suppressor that inhibits angiogenesis by repressing VEGF production in epithelial cells.
|
28408355 |
2017 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Deleted in Liver Cancer 1 (DLC1) is a tumor suppressor gene frequently deleted in cancer.
|
29202196 |
2018 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC1 was also identified as an estrogen-induced tumor suppressor in the normal mammary gland with decreased expression in breast cancer.
|
31110002 |
2019 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Deleted in Liver Cancer 1 (DLC1) is a tumor suppressor gene deleted in many cancers, including angiosarcoma, an aggressive malignancy of endothelial cell derivation.
|
31409902 |
2019 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
DLC-1 may be a tumor suppressor gene in liver cancer as well as in other cancers.
|
9605766 |
1998 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
A tumor suppressor Deleted in Liver Cancer 1 (DLC1) has been reported to be down-regulated or even silenced in several kinds of cancer including breast cancer.
|
27830358 |
2017 |
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
A tumor suppressor DLC1: The functions and signal pathways.
|
31773748 |
2020 |