DLC1, DLC1 Rho GTPase activating protein, 10395

N. diseases: 144; N. variants: 21
Disease: Adult Angiosarcoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0278592
Disease: Adult Angiosarcoma
Adult Angiosarcoma 		0.020 Biomarker disease BEFREE These results identify YAP as a previously unrecognized effector of DLC1 deficiency-associated loss of cell contact growth inhibition in endothelial cells and a potential therapeutic target in angiosarcoma. 31409902 2019
CUI: C0278592
Disease: Adult Angiosarcoma
Adult Angiosarcoma 		0.020 Biomarker disease BEFREE Consistently, we found that DLC1 is statistically significantly reduced (P < .001 in 5 of 6) and TNFAIP3/A20 is statistically significantly increased (P < .001 in 2 of 3 and P = 0.02 in 1 of 3) in human angiosarcoma compared with normal adjacent endothelium. 29202196 2018