DLC1, DLC1 Rho GTPase activating protein, 10395

N. diseases: 144; N. variants: 21
Disease: Hepatocarcinogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis 		0.070 Biomarker disease BEFREE Deleted in liver cancer‑1 (DLC‑1), a candidate tumor suppressor gene which is inactive in liver carcinogenesis, is located at 8p21.3, where deletions are frequently found in several types of human cancer. 23783552 2013
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis 		0.070 Biomarker disease BEFREE DLC-1 (deleted in liver cancer-1) is a potential tumor suppressor gene, which is inactive in liver carcinogenesis. 18288400 2008
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis 		0.070 Biomarker disease BEFREE Deleted in liver cancer-1 (DLC-1) is a tumour suppressor gene that is inactive in liver carcinogenesis. 16489177 2006
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis 		0.070 Biomarker disease BEFREE These observations thus support the notion that Dlc-1 protein is involved in hepatocarcinogenesis and has oncosuppressive activity in HCC. 14647417 2004
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis 		0.070 Biomarker disease BEFREE DLC1, a tumour suppressor gene inactivated in liver carcinogenesis and encoding a Rho GTPase activating protein (RhoGAP) maps to one of the deleted regions (8p21.3-22). 15159023 2004
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis 		0.070 PosttranslationalModification disease BEFREE Taken together, the results of our study suggest that both genetic and epigenetic alterations play an important role in inactivation of the DLC-1 gene in hepatocarcinogenesis. 14633684 2003
CUI: C1512409
Disease: Hepatocarcinogenesis
Hepatocarcinogenesis 		0.070 Biomarker disease BEFREE Our findings suggest that DLC-1 may play an important role in hepatocarcinogenesis. 11118037 2000