|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In particular, the MCPyV early gene downregulated the expression of the tumor suppressor gene N-myc downstream regulated gene-1 (NDRG1) in NIKs-MCPyV and hTERT-MCPyV human keratinocytes (HK) as compared to their controls.
|
31694959 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Previous studies have reported that deregulated expression of N-myc downstream regulated gene 1 (NDRG1) affects tumor growth and clinical outcomes of patients with various types of cancer including glioma.
|
31723002 |
2020 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NDRG1 inhibited tumor proliferation through increasing p21 expression via suppressing p21 ubiquitylation.
|
31831018 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
NDRG1 protein levels were significantly increased in bladder cancer patients and correlated with tumour stage (p = 0.025), lymph node metastasis (p = 0.034) and overall survival (p = 0.016).
|
30914736 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The molecular mechanism(s) underlying NDRG1 pleiotropy remain elusive, but are linked to differential regulation of WNT signaling and potentially differential interaction with the tumor suppressor, PTEN.
|
31132412 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NDRG1 suppresses vasculogenic mimicry and tumor aggressiveness in gastric carcinoma.
|
31452779 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Intriguingly, pSTAT6/C-C motif chemokine ligand 26 (CCL26) signaling is induced by FOXQ1/NDRG1 axis, thus recruiting hepatic stellate cells (HSCs), the main cellular source of CAFs, to the tumor microenvironment.
|
29248714 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
<i>N</i>-myc downstream regulated gene 1 (NDRG1) is demonstrated as a tumor suppressor gene in several cancers.
|
29738439 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Analysis of changes in gene expression after MALAT-1 knockdown shows that this lncRNA represses several tumor suppressor-like genes including N-myc downregulated gene-1 (NDRG-1), a tumor suppressor in pancreatic cancer that is also corepressed by EZH2 (a PRC2 complex member).
|
29389953 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This study reveals that all members display a differential expression pattern in the gut and that NDRG1, NDRG2 and NDRG4 (1) can serve as biomarker for colorectal cancer and (2) have tumor suppressive properties mainly affecting cell proliferation and epithelial-mesenchymal transition.
|
30033230 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The role of NDRG1, a hypoxia-inducible protein; FOXOs, which are tumor suppressor proteins; and the mTOR complex 2 pathway in infantile haemangioma have not been studied yet.
|
29569762 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Further, more NDRG1 expression was detected in the subset of PCa cells with reduced expression of H3K9me3 or H3K27me3 in the tumors generated by 5-Aza pretreated PCa cells and critically, these biological differences are also observed in small cell carcinoma in advanced stage of human primary PCa tumors.
|
29236331 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We investigated the expression of NDRG1 in pancreatic cancer tissues and cell lines as well as how it affects tumor growth, invasion and migration in pancreatic cancer cells.
|
28075464 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Currently regarded as a tumor suppressor in most studies, NDRG1 is abundant in prostate, brain, kidney, placental, and intestinal tissues.
|
29283328 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition, NDRG1 inhibited tumor growth and promoted apoptosis in mouse xenograft model.
|
28537875 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
N-myc downstream-regulated gene 1 (NDRG1) is a tumor suppressor with the potential to suppress metastasis, invasion and migration of cancer cells.
|
28498432 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Moreover, NDRG1 expression negatively correlated to tumor size and clinical TNM stage, suggesting that NDRG1 might act as a tumor suppressor by inhibiting proliferation or inducing apoptosis in CRC.
|
29137287 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Previously, we reported that N-myc downstream-regulated gene 1 (NDRG1) is strongly up-regulated under hypoxia and may play an important role in tumor adaptation to fluctuating oxygen concentrations.
|
26852918 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We showed for the first time that the N-myc downstream regulated gene 1 (NDRG1) and NDRG2, known as tumor suppressor genes, are negatively regulated by LCN2 in CCA cells.
|
27782193 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
NDRG1 expression was correlated inversely with the degree of tumor cell differentiation (p < 0.01), invasion depth (p < 0.05), lymph node metastasis (p < 0.05) and TNM stage (p < 0.05), whereas MMP-9 was positive correlated with the degree of tumor cell differentiation (p < 0.01), lymph node metastasis (p < 0.05) and TNM stage (p < 0.05), but not correlated with invasion depth (p>0.05).
|
27154576 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Orthotopically implanted NDRG1 glioma showed reduced tumor growth and vessel density compared to controls.
|
26297987 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here, we show that NDRG1 overexpression (91.9%, 79/86) in ESCC tumor tissues is associated with poor overall survival of esophageal cancer patients.
|
27414086 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
NDRG1 plays important roles in tumor growth and metastasis of colorectal cancer (CRC).
|
27338835 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The N-myc downstream regulated gene (NDRG) family of NDRG1, 2, 3, and mammary serine protease inhibitor (Maspin) gene are well-known modulators in the neoplasia process.
|
27589737 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The N-myc downstream regulated gene 1 (NDRG1) is significantly associated with advanced tumor stages and poor survival of hepatocellular carcinoma (HCC), thereby implicating it as a potential target for HCC treatment.
|
26359353 |
2015 |