|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
N-myc downstream-regulated gene 1 (NDRG1) has been shown to play a key role in tumor metastasis.
|
31831018 |
2019 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The current study is the first to elucidate a unique facet of the potent tumor/metastasis suppressor NDRG1 in the regulation of PDAC glycolysis, leading to important insights into the mechanism by which NDRG1 exert inhibitory function in PDAC.
|
28350132 |
2017 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
N-myc downstream-regulated gene 1 (NDRG1) has been reported to act as a key regulatory molecule in tumor progression-related signaling pathways, especially in tumor metastasis.
|
28346422 |
2017 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The protein N-myc down-regulated gene 1 (NDRG1) represses tumour metastasis.
|
28545025 |
2017 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo local tumors were 5.9-fold larger (p = 0.006) and the number of metastases was higher in animals with tumors silenced for NDRG1 primarily (3 vs. 1.1; p = 0.005) and at recurrence (3.3 vs. 0.9; p = 0.015).
|
24970329 |
2014 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
NDRG1 (N-myc downstream-regulated gene 1) plays a role in cell differentiation and suppression of tumor metastasis.
|
23099645 |
2013 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
N-Myc downstream-regulated gene 1 (NDRG1) plays vital roles in tumor metastasis suppression and is frequently silenced in metastatic colon cancers.
|
21184144 |
2011 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A combined analysis showed higher immunohistochemical expression of NDRG1 in malignant lesions (classical pattern and follicular variant of papillary thyroid carcinomas, follicular carcinomas, and metastases of thyroid carcinomas) compared to benign thyroid lesions (goiter and follicular adenomas) (P = 0.043).
|
20835551 |
2010 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
NDRG1 is up-regulated by cell differentiation signals in various cancer cell lines and suppresses tumor metastasis.
|
17916902 |
2008 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, Ndrg-1 expression was shown to be negatively correlated with tumor metastasis.
|
16920733 |
2006 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our immunohistochemical analysis on prostate cancer specimens revealed that nuclear expression of ATF3 was inversely correlated to Drg-1 expression and positively correlated to metastases.
|
17178897 |
2006 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
On the other hand, we and others have demonstrated that the Drg-1 gene suppresses prostate and colon cancer metastases in mouse models.
|
15184886 |
2004 |
|
Secondary Neoplasm
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we explored the possibility that PTEN controls tumor metastasis by regulating the expression of the Drg-1 gene.
|
15520163 |
2004 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The role of NDRG1 in tumor metastatic process can be demonstrated by in vivo and in vitro.
|
14966915 |
2004 |
|
Secondary Neoplasm
|
0.100 |
Biomarker
|
group |
BEFREE |
The Drg-1 gene suppresses tumor metastasis in prostate cancer.
|
12702552 |
2003 |