Disease: Retinal Diseases ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.020 AlteredExpression group BEFREE Oxygen-induced retinopathy was induced in mice and EPAC-1 expression investigated by immunofluorescence. 28353063 2017
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.020 Biomarker group BEFREE Epac1-deficient mice showed a reduced amount of pre-retinal neovascularizations in the model of oxygen-induced retinopathy, which is predominantly driven by vascular endothelial growth factor (VEGF). siRNA-mediated knockdown of Epac1 in human umbilical vein EC (HUVEC) decreased angiogenic sprouting by lowering the expression of the endothelial VEGF-receptor-2 (VEGFR-2). 28512254 2017