|
Chronic Obstructive Airway Disease
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that roflumilast inhibits neutrophil chemotaxis directly via a cAMP-mediated mechanism requiring activation of Epac1 and that Epac1 activators could reduce COPD neutrophilic inflammation.
|
30395484 |
2019 |
|
Obesity
|
0.320 |
Biomarker
|
disease |
CTD_human |
We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR.
|
29273807 |
2018 |
|
Obesity
|
0.320 |
Biomarker
|
disease |
BEFREE |
The function of Epac1 on obesity was unveiled using Epac1 knockout (KO) mice.
|
27867203 |
2017 |
|
Obesity
|
0.320 |
Biomarker
|
disease |
BEFREE |
While global deletion of Epac1 in mice leads to heightened leptin sensitivity in the hypothalamus and partial protection against high-fat diet (HFD)-induced obesity, the physiological functions of Epac1 in white adipose tissue (WAT) has not been explored.
|
27381457 |
2016 |
|
Chronic Obstructive Airway Disease
|
0.320 |
Biomarker
|
disease |
CTD_human |
Importantly, Epac1 expression was also reduced in lung tissue from COPD patients.
|
22363678 |
2012 |
|
Chronic Obstructive Airway Disease
|
0.320 |
AlteredExpression
|
disease |
BEFREE |
Importantly, Epac1 expression was also reduced in lung tissue from COPD patients.
|
22363678 |
2012 |
|
Impaired glucose tolerance
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Role of Exchange Protein Directly Activated by Cyclic AMP Isoform 1 in Energy Homeostasis: Regulation of Leptin Expression and Secretion in White Adipose Tissue.
|
27381457 |
2016 |
|
Rickettsia Infections
|
0.300 |
Biomarker
|
group |
CTD_human |
Our results demonstrate that Epac1-mediated signaling represents a mechanism for host-pathogen interactions and that Epac1 is a potential target for the prevention and treatment of fatal rickettsioses.
|
24218580 |
2013 |
|
Tick-Borne Infections
|
0.300 |
Biomarker
|
group |
CTD_human |
Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses.
|
24218580 |
2013 |
|
Tick-Borne Diseases
|
0.300 |
Biomarker
|
group |
CTD_human |
Exchange protein directly activated by cAMP plays a critical role in bacterial invasion during fatal rickettsioses.
|
24218580 |
2013 |
|
Kidney Failure, Acute
|
0.300 |
Biomarker
|
disease |
CTD_human |
cAMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac.
|
21745194 |
2012 |
|
Chronic Airflow Obstruction
|
0.300 |
Biomarker
|
disease |
CTD_human |
Anti-inflammatory role of the cAMP effectors Epac and PKA: implications in chronic obstructive pulmonary disease.
|
22363678 |
2012 |
|
Acute Kidney Insufficiency
|
0.300 |
Biomarker
|
disease |
CTD_human |
cAMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac.
|
21745194 |
2012 |
|
Acute kidney injury
|
0.300 |
Biomarker
|
disease |
CTD_human |
cAMP signalling protects proximal tubular epithelial cells from cisplatin-induced apoptosis via activation of Epac.
|
21745194 |
2012 |
|
Graft Rejection
|
0.200 |
Therapeutic
|
phenotype |
RGD |
Treatment with alpha-melanocyte stimulating hormone preserves calcium regulatory proteins in rat heart allografts.
|
18178058 |
2008 |
|
Cardiomegaly
|
0.200 |
Biomarker
|
phenotype |
RGD |
Epac mediates beta-adrenergic receptor-induced cardiomyocyte hypertrophy.
|
18323524 |
2008 |
|
Arterial Injury, CTCAE
|
0.200 |
Biomarker
|
phenotype |
RGD |
Epac1 is upregulated during neointima formation and promotes vascular smooth muscle cell migration.
|
18689492 |
2008 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Waist-Hip Ratio
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Body mass index
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity.
|
29273807 |
2018 |
|
Blood Protein Measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Co-regulatory networks of human serum proteins link genetics to disease.
|
30072576 |
2018 |
|
Malignant Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
PDE4 and Epac1 expression levels are increased in rectal carcinoma tissues, suggesting that the two proteins may be involved in the development of this malignancy.
|
30809467 |
2019 |
|
Primary malignant neoplasm
|
0.070 |
AlteredExpression
|
group |
BEFREE |
PDE4 and Epac1 expression levels are increased in rectal carcinoma tissues, suggesting that the two proteins may be involved in the development of this malignancy.
|
30809467 |
2019 |
|
Malignant Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
These data provide mechanistic insight into the role of EPAC1 in regulating the tumor microenvironment, iMVD and cancer cell-induced angiogenesis, a dynamic mechanism under drug pressure that may associate to treatment failure.
|
29982410 |
2018 |
|
Malignant Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Epac1 expression was associated with the degree of malignancy and lymph node metastasis (P < 0.05), but not with histological type (P > 0.05), whereas PKC expression was not related to these parameters.
|
29528086 |
2018 |