Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Decreased miR-424-5p expression and increased YAP1 expression are found in patients with liver cancer.
|
30676784 |
2019 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We and others have demonstrated that the genetic disruption of kinases Mst1 and Mst2 (Mst1/2), the core components of Hippo signaling, results in YAP activation and sustained liver growth, thereby leading to an eight- to tenfold increase in liver size within 3 months and occurrence of liver cancer within 5 months (Curr Biol 17(23):2054-2060, 2007; Cancer Cell 16(5):425-438, 2009; Cell 130(6):1120-1133, 2007; Cancer Cell 31(5):669-684 e667, 2017; Nat Commun 6:6239, 2015; Cell Rep 3(5):1663-1677, 2013).
|
30565146 |
2019 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Role of Glypican-3 in Regulating Wnt, YAP, and Hedgehog in Liver Cancer.
|
31428581 |
2019 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Peritumoral activation of the Hippo pathway effectors YAP and TAZ suppresses liver cancer in mice.
|
31754005 |
2019 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of YAP1 showed great association with poorer prognosis in patients with various cancers, particularly liver cancer.
|
31613226 |
2019 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we found that Tanshinone IIA mediates SMAD7-YAP interaction to induce liver cancer cell apoptosis and inhibit cell growth and migration by inactivating the transforming growth factor beta (TGF-β) signaling pathway.
|
31711043 |
2019 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Taken together, our findings suggest that YAP1, highly expressed in malignant liver tumours, contributes to hepatocellular CSCs phenotype and is a molecular target of interest for CSCs targeted therapy in liver cancer patients.
|
29698666 |
2018 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
NUAK2 is a critical YAP target in liver cancer.
|
30446657 |
2018 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We further show that Agrin promotes oncogenesis through YAP-dependent transcription and is clinically relevant in human liver cancer.
|
28273460 |
2017 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
On the other hand, human liver cancer tissue microarray (TMA) shown YAP1 expression was closely to clinic.
|
29187885 |
2017 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The hippo pathway leads to phosphorylation of the transcriptional activator yes-associated protein 1 (YAP1, YAP), which regulates proliferation and has been associated with the development of liver cancer.
|
28249813 |
2017 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Overall, Scrib inhibits liver cancer cell proliferation by suppressing the expression of three oncogenes, Yap1, c-Myc and cyclin D1, thereby functioning as a tumor suppressor in liver cancer.
|
28460446 |
2017 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Overexpression of LATS1 and the nucleocytoplasmic translocation of YAP1 play an anti-oncogenetic role in the occurrence and development of liver cancer.
|
28076850 |
2017 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we find a strong correlation between YOD1 and YAP expression in liver cancer patients.
|
28416659 |
2017 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, a strong correlation was observed between YOD1 and YAP expression in liver cancer patients.
|
28502290 |
2017 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our previously study demonstrated that CD166 exerts its anti-apoptotic role through interaction with YAP in liver cancer.
|
25094049 |
2014 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We used immunohistochemical analysis to determine expression of β-catenin and Yap1 in liver cancer specimens collected from patients in Europe and the United States, consisting of 104 hepatocellular carcinoma, 62 intrahepatic cholangiocarcinoma, and 94 hepatoblastoma samples.
|
24837480 |
2014 |
Adult Liver Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Using ChIP-on-chip screens and ChIP assays, we find that menin occupancy frequently coincides with H3K4me3 at the promoter of many liver cancer-related genes, such as Yes-associated protein (Yap1).
|
24101467 |
2013 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Altogether, our study uncovers a regulatory mechanism underlying liver cancer-specific Wnt transcriptional output, and suggests that TRIB2 functions as a signaling nexus to integrate the Wnt/β-catenin, Hippo/YAP, and C/EBPα pathways in cancer cells.
|
23769673 |
2013 |
Adult Liver Carcinoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to measure YAP gene expression and protein levels during rat liver regeneration and in liver cancer, and to explore possible correlations between YAP levels and cancer cell proliferation following partial hepatectomy.
|
22012126 |
2012 |