SPON2, spondin 2, 10417

N. diseases: 34; N. variants: 1
Disease: Secondary Neoplasm ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.030 Biomarker group BEFREE Spondin 2 (SPON2), a member of the Mindin F-Spondin family, identifies pathogens, activates congenital immunity and promotes the growth and adhesion of neurons as well as binding to their receptors, but its role in promoting or inhibiting tumour metastasis is controversial. 31691494 2020
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.030 Biomarker group BEFREE Here we report that, in the tumor microenvironment of hepatocellular carcinoma (HCC), SPON2 not only promotes infiltration of M1-like macrophages but also inhibits tumor metastasis. 29440144 2018
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.030 AlteredExpression group BEFREE Tumors with SPON2 overexpression induced liver metastasis (vs control animals without any metastases, P=0.0036). 26686083 2016