|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
The variability in expression of CDX1 in gastric and esophageal adenocarcinomas suggests more than one pathway in the development of these carcinomas.
|
9247467 |
1997 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Sox2 was found to be transcribed in G and GI-mixed type adenocarcinomas in accordance with MUC5AC and MUC6 expression, while Cdx1 and Cdx2 were up-regulated in GI-mixed and I types along with the expression of MUC2 and villin.
|
15910596 |
2005 |
|
Adenocarcinoma of colon
|
0.020 |
Biomarker
|
disease |
BEFREE |
Non-transformed intestinal IEC-6 cells and colon adenocarcinoma SW480 cells were used to study the putative molecular relationship between Cdx1, p53, p21(WAF), and Bcl-2.
|
12270138 |
2002 |
|
Adenocarcinoma of colon
|
0.020 |
Biomarker
|
disease |
BEFREE |
To explore the role of homeobox genes in the intestine, the human colon adenocarcinoma cell line Caco2-TC7 has been stably transfected with plasmids synthesizing Cdx1 and Cdx2 sense and antisense RNAs.
|
9396760 |
1997 |
|
Adenosquamous carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Four pancreatic ductal adenocarcinoma cell lines (PancQGO-1, BxPC-3, MIAPaCa-2, CFPAC-1), 1 islet carcinoma cell line (QGP-1), and 1 adenosquamous carcinoma cell line (KP-3) were analyzed for CDX1 and CDX2 expression using real-time reverse transcription-polymerase chain reaction and Western blot analysis.
|
19106744 |
2009 |
|
Anorectal Malformations
|
0.320 |
AlteredExpression
|
group |
BEFREE |
Down regulation of CDX-1 gene has also been implicated in isolated ARM patients.
|
29094201 |
2018 |
|
Anorectal Malformations
|
0.320 |
Biomarker
|
group |
GENOMICS_ENGLAND |
Spatiotemporal distribution of caudal-type homeobox proteins during development of the hindgut and anorectum in human embryos.
|
27042391 |
2016 |
|
Anorectal Malformations
|
0.320 |
AlteredExpression
|
group |
BEFREE |
Furthermore, it was suggested that the downregulation of CDX1 might be related to the development of ARMs.
|
23329892 |
2013 |
|
Arnold-Chiari Malformation, Type I
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Multiple marker analysis identified a risk haplotype for classical CMI in ALDH1A2 and CDX1.
|
23437350 |
2013 |
|
Barrett Epithelium
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In contrast to CDX2, CDX1 was expressed only in Barrett's epithelium.
|
12560917 |
2003 |
|
Barrett Esophagus
|
0.070 |
Biomarker
|
disease |
BEFREE |
CDX1/2 targets were, however, not enriched, suggesting that although CDX1/2 activation reportedly plays a role in BM development, it may not be an initial event.
|
24713057 |
2014 |
|
Barrett Esophagus
|
0.070 |
Biomarker
|
disease |
BEFREE |
Our data suggested an important role of CDX1 and CDX2 in the development of BE.
|
19468668 |
2009 |
|
Barrett Esophagus
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
In addition to upregulation of CDX1 and CDX2, ASBT expression is up-regulated in BE.
|
23687410 |
2013 |
|
Barrett Esophagus
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Although the initial trigger for CDX1 promoter demethylation is not yet identified, it seems likely that demethylation of its promoter may be the key to the induction and maintenance of CDX1 expression and so of the BM phenotype.
|
15894614 |
2005 |
|
Barrett Esophagus
|
0.070 |
Biomarker
|
disease |
BEFREE |
These data demonstrate the ability of Cdx1 and c-myc to initiate the earliest stages of transdifferentiation of esophageal keratinocytes toward a cell fate characteristic of Barrett's esophagus.
|
18953412 |
2008 |
|
Barrett Esophagus
|
0.070 |
AlteredExpression
|
disease |
BEFREE |
Ectopic expression of Cdx1 and Cdx2 occurs in both gastric IM as well as in BE.
|
21075347 |
2010 |
|
Barrett Esophagus
|
0.070 |
Biomarker
|
disease |
BEFREE |
Genomic DNA was extracted from blood samples collected from BE (n = 109) and GERD (n = 223) patients for genotyping of 5 SNPs each of Cdx1 and Cdx2 using TaqMan allelic discrimination assays.
|
23918153 |
2014 |
|
Barrett Esophagus
|
0.070 |
Biomarker
|
disease |
LHGDN |
Cdx1 and c-Myc foster the initiation of transdifferentiation of the normal esophageal squamous epithelium toward Barrett's esophagus.
|
18953412 |
2008 |
|
Carcinogenesis
|
0.080 |
GeneticVariation
|
phenotype |
BEFREE |
Because the Cdx1 homeobox gene stimulates proliferation and induces transformation and tumorigenesis, it has been investigated whether it is involved in the complex network comprising p53, p21(WAF), and Bcl-2 in intestinal epithelial cells.
|
12270138 |
2002 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Notably, the concomitant loss of Cdx1 led to a significant increase in the incidence of tumors in the distal colon, relative to APC(Min/+)-Cdx2 offspring, demonstrating a previously unrecognized role for this transcription factor in colorectal tumorigenesis.
|
25320087 |
2014 |
|
Carcinogenesis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
It was concluded that decrease in human Cdx1 and/or Cdx2 expression is associated with colorectal tumorigenesis.
|
9036867 |
1997 |
|
Carcinogenesis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
We have previously described an inverse relationship between Cdx1 and Cdx2 mRNA levels and the extent of dysplasia and severity of clinical outcome in colorectal carcinoma, suggesting that altered expression of these genes was associated with colorectal carcinogenesis or tumor progression.
|
9593754 |
1998 |
|
Carcinogenesis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, these functionally interacting events drive CDX1 expression and contribute to intestinal metaplasia, epithelial dedifferentiation, and carcinogenesis in the human stomach.
|
22749770 |
2012 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
IMPLICATIONS: This study shows that CDX1 contributes to the tumorigenesis and progression of gastric cancer and suggests the potential of targeting CDX1 to treat this malignancy.
|
31416838 |
2019 |
|
Carcinogenesis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
Overall our findings show that downregulation of CDX1 and EphB receptor genes occurs independently and that different branches of epigenetic control systems including class I and III HDACs contribute to epigenetic silencing of Wnt/β-catenin targets during colorectal tumorigenesis.
|
21393996 |
2011 |