|
Anorectal Malformations
|
0.320 |
AlteredExpression
|
group |
BEFREE |
Down regulation of CDX-1 gene has also been implicated in isolated ARM patients.
|
29094201 |
2018 |
|
Anorectal Malformations
|
0.320 |
Biomarker
|
group |
GENOMICS_ENGLAND |
Spatiotemporal distribution of caudal-type homeobox proteins during development of the hindgut and anorectum in human embryos.
|
27042391 |
2016 |
|
Anorectal Malformations
|
0.320 |
AlteredExpression
|
group |
BEFREE |
Furthermore, it was suggested that the downregulation of CDX1 might be related to the development of ARMs.
|
23329892 |
2013 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Intestinal-type gastric cancer often results from <i>Helicobacter pylori</i> infection through intestinal metaplasia, a transdifferentiated premalignant phenotype.Because <i>H. pylori</i> virulence factor CagA has been associated with aberrant expression of the transcription factor CDX1, which regulates intestinal differentiation, we explored its relationship with <i>H. pylori</i> infection and function during gastric carcinogenesis in normal gastric epithelial cells and gastric cancer cell lines.
|
31416838 |
2019 |
|
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study was to compare CDX1 and A33 with CDX2 as immunomarkers for CRC.
|
28226180 |
2017 |
|
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
N-glycosylation Profiling of Colorectal Cancer Cell Lines Reveals Association of Fucosylation with Differentiation and Caudal Type Homebox 1 (CDX1)/Villin mRNA Expression.
|
26537799 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A subgroup analysis revealed a difference in prognosis between groups with low and high CDX1 expression among patients who had tumors <5 cm in size and who were alpha-fetoprotein (AFP) negative.
|
27566019 |
2016 |
|
Intestinal metaplasia
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
ISX expression induced by H. pylori infection may lead to IM and hyperproliferation of gastric mucosa through CDX1/2 and cyclinD1 expression, contributing to gastric carcinogenesis.
|
26872890 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, a histological analysis revealed that Cdx1 derepression in the DNA-hypomethylated tumors is correlated with the differentiation of colon tumor cells.
|
25939752 |
2015 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Recently, two fusion genes were described in mesenchymal chondrosarcomas: a recurrent HEY1-NCOA2 found in tumors that had not been cytogenetically characterized and an IRF2BP2-CDX1 found in a tumor carrying a t(1;5)(q42;q32) translocation as the sole chromosomal abnormality.
|
24839999 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Cdx1 and Cdx2 function as tumor suppressors.
|
25320087 |
2014 |
|
Colorectal Carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Taken together, these results suggest that ROS-induced oxidative stress silences the tumor suppressor CDX1 through epigenetic regulation, and may therefore be associated with the progression of colorectal cancer.
|
23618814 |
2013 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
There was no difference of gene expression of CDX1 and CDX2 between tumour or tumour-adjacent and tumour-distant mucosa, but both factors were significantly higher expressed in cancer patients compared with controls (p<0.01).
|
23613102 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, these results suggest that ROS-induced oxidative stress silences the tumor suppressor CDX1 through epigenetic regulation, and may therefore be associated with the progression of colorectal cancer.
|
23618814 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Intratumoral injection of Cdx1 siRNA significantly inhibited tumor growth in a xenograft tumor model inoculated with CD44(+)CD24(+)Cdx1(+) cancer cells.
|
23624503 |
2013 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Expression of CDX1 and CDX2 was higher in the presence of intestinal metaplasia.
|
23613102 |
2013 |
|
Colorectal Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These findings demonstrate that loss of villin expression due to Cdx-1 loss is a feature of poorly differentiated CRCs.
|
22349300 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The IRF2BP2-CDX1 has not formerly been described in human neoplasia.
|
23185413 |
2012 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, these functionally interacting events drive CDX1 expression and contribute to intestinal metaplasia, epithelial dedifferentiation, and carcinogenesis in the human stomach.
|
22749770 |
2012 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our study places the stemness-related reprogramming factors as critical components of CDX1-directed transcriptional circuitries that promote intestinal metaplasia.
|
23112162 |
2012 |
|
Colorectal Carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing of CDX1 and EPHB tumor suppressor genes in colorectal cancer.
|
21393996 |
2011 |
|
Neoplasms
|
0.100 |
PosttranslationalModification
|
group |
BEFREE |
Class I and III HDACs and loss of active chromatin features contribute to epigenetic silencing of CDX1 and EPHB tumor suppressor genes in colorectal cancer.
|
21393996 |
2011 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
CDX1 and CDX2 expression increased proportional to the IM grade of the body (P < 0.001).
|
21532856 |
2011 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Ectopic expression of Cdx1 and Cdx2 occurs in both gastric IM as well as in BE.
|
21075347 |
2010 |
|
Colorectal Carcinoma
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
This could, therefore, explain the relatively frequent down regulation of CDX1 in colorectal carcinomas by hypermethylation.
|
19188603 |
2009 |