|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Intestinal-type gastric cancer often results from <i>Helicobacter pylori</i> infection through intestinal metaplasia, a transdifferentiated premalignant phenotype.Because <i>H. pylori</i> virulence factor CagA has been associated with aberrant expression of the transcription factor CDX1, which regulates intestinal differentiation, we explored its relationship with <i>H. pylori</i> infection and function during gastric carcinogenesis in normal gastric epithelial cells and gastric cancer cell lines.
|
31416838 |
2019 |
|
Intestinal metaplasia
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
ISX expression induced by H. pylori infection may lead to IM and hyperproliferation of gastric mucosa through CDX1/2 and cyclinD1 expression, contributing to gastric carcinogenesis.
|
26872890 |
2016 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Expression of CDX1 and CDX2 was higher in the presence of intestinal metaplasia.
|
23613102 |
2013 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
In conclusion, these functionally interacting events drive CDX1 expression and contribute to intestinal metaplasia, epithelial dedifferentiation, and carcinogenesis in the human stomach.
|
22749770 |
2012 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Our study places the stemness-related reprogramming factors as critical components of CDX1-directed transcriptional circuitries that promote intestinal metaplasia.
|
23112162 |
2012 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
CDX1 and CDX2 expression increased proportional to the IM grade of the body (P < 0.001).
|
21532856 |
2011 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Ectopic expression of Cdx1 and Cdx2 occurs in both gastric IM as well as in BE.
|
21075347 |
2010 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Here, we examine intestinal metaplasia in molecular terms, noting the over-expression of Cdx1, Cdx2, Pdx1, Oct1, TFF3 and the downregulation of Hedgehog signalling; Runx3 is deactivated by epigenetic silencing, and pathways such as Wnt and MARK/ERK are involved.
|
18400571 |
2008 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
Finally, it was verified that the expression of COX-2, CDX1, SHP and CCAAT element-binding protein beta messenger RNA in human IM lesions were significantly higher than in lesions associated with gastritis.
|
18775915 |
2008 |
|
Intestinal metaplasia
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
On the other hand, Cdx1 (G vs GI and GI vs I, P<0.0001 and P=0.337, respectively) and Cdx2 (G vs GI and GI vs I, P<0.0001 and P<0.05, respectively) appeared in IM.
|
14655050 |
2004 |
|
Intestinal metaplasia
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The involvement of Cdx-1 and Cdx-2 in the intestinal development and their role in transcription of several intestinal genes support the hypothesis that Cdx-1 and/or Cdx-2 play important roles in the aberrant intestinal differentiation program of intestinal metaplasia and gastric carcinoma.
|
14525978 |
2003 |
|
Intestinal metaplasia
|
0.100 |
Biomarker
|
phenotype |
BEFREE |
The expression of CDX2 precedes those of CDX1, sucrase-isomaltase, other intestine-specific genes (human defensin-5, alkaline phosphatase), and MUC2 during the progression of intestinal metaplasia.
|
11871772 |
2002 |
|
Intestinal metaplasia
|
0.100 |
AlteredExpression
|
phenotype |
BEFREE |
The aims of this study were: (1) to assess the normal tissue expression patterns of Cdx1 and Cdx2 in the human gastrointestinal tract and (2) to ascertain levels in intestinal metaplasia (IM) of the stomach associated with gastritis.
|
11846061 |
2001 |