CDX2, caudal type homeobox 2, 1045

N. diseases: 278; N. variants: 4
Disease: Colonic Polyps ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0009376
Disease: Colonic Polyps
Colonic Polyps 		0.050 AlteredExpression phenotype BEFREE A tumor suppressor function is suggested by evidence that CDX2 levels are decreased in human colon cancer specimens and that an inactivating mutation of Cdx2 in Apc(Δ716) mice markedly increases the incidence of colonic polyps. 21224344 2011
CUI: C0009376
Disease: Colonic Polyps
Colonic Polyps 		0.050 GeneticVariation phenotype BEFREE CDX2 heterozygous mutant mice develop colonic polyps, and loss of CDX2 expression is seen in a subset of colon carcinomas in humans. 20699370 2010
CUI: C0009376
Disease: Colonic Polyps
Colonic Polyps 		0.050 AlteredExpression phenotype BEFREE Mice heterozygous for Cdx2 inactivation develop colonic polyps with epithelial cells showing gastric or squamous differentiation. 15825077 2005
CUI: C0009376
Disease: Colonic Polyps
Colonic Polyps 		0.050 Biomarker phenotype BEFREE Here we show that the colonic polyp number is about six times higher in Apc+/Delta716 Cdx2+/- compound mutant mice. 14625550 2003
CUI: C0009376
Disease: Colonic Polyps
Colonic Polyps 		0.050 GeneticVariation phenotype BEFREE Inactivation of one Cdx2 allele predisposes mice to develop colon polyps, and loss of CDX2 expression is a feature of some poorly differentiated colon carcinomas in humans. 12404231 2002