CDX2, caudal type homeobox 2, 1045
N. diseases: 278; N. variants: 4
Source: ALL
| Disease | Score gda | Association Type | Type | Original DB | Sentence supporting the association | PMID | PMID Year |
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0.070 | AlteredExpression | disease | BEFREE | HP<sub>CagA+VacA+</sub> up-regulated zincfinger ebox binding homeobox 1 (ZEB1) in AGS cells after co-culturing for 24 h. Expression of caudal type homeobox transcription factor (CDX-2) and claudin-2 was significantly increased by HP<sub>CagA+VacA+</sub> (P<0.05), but not by HP<sub>CagA-VacA-</sub>. | 28819779 | 2020 |
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0.070 | AlteredExpression | disease | BEFREE | Helicobacter pylori induces caudal-type homeobox protein 2 and cyclooxygenase 2 expression by modulating microRNAs in esophageal epithelial cells. | 29215765 | 2018 |
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0.070 | AlteredExpression | disease | BEFREE | Ectopic expression of CDX2 in the stomach is closely associated with chronic Helicobacter pylori (H. pylori) infection and intestinal metaplasia. | 23317240 | 2012 |
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0.070 | AlteredExpression | disease | BEFREE | Chronic infection with Helicobacter pylori is a major cause of gastric intestinal metaplasia, and aberrant induction by H. pylori of the intestine-specific caudal-related homeobox (CDX) transcription factors, CDX1 and CDX2, plays a key role in this metaplastic change. | 23112162 | 2012 |
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0.070 | AlteredExpression | disease | BEFREE | Helicobacter pylori and the BMP pathway regulate CDX2 and SOX2 expression in gastric cells. | 22791809 | 2012 |
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0.070 | AlteredExpression | disease | BEFREE | Different Helicobacter pylori genotypes are associated with distinct inflammatory responses and consequent development of pre-neoplastic lesions, namely intestinal metaplasia (IM), which is dependent on the expression of CDX2. | 20367284 | 2010 |
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0.070 | AlteredExpression | disease | BEFREE | Helicobacter pylori-associated atrophic gastritis is characterized by aberrant expression of CDX2. | 20110706 | 2010 |