MERTK, MER proto-oncogene, tyrosine kinase, 10461

N. diseases: 154; N. variants: 31
Disease: Fibrosis, Liver ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.050 Biomarker disease BEFREE We now show that holo- or myeloid-specific Mertk targeting in NASH mice decreases liver fibrosis, congruent with the human genetic data. 31839486 2020
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.050 Biomarker disease BEFREE Gas6/TAM system (mainly, Axl and MERTK) has in fact recently emerged as an important player in the progression of liver fibrosis. 31583026 2019
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.050 Biomarker disease BEFREE The loss-of-function rs4374383 G > A variant in Myeloid-epithelial-reproductive Tyrosine Kinase (MERTK) gene has been linked to hepatic fibrosis in chronic liver diseases. 28334911 2017
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.050 GeneticVariation disease BEFREE This variant also shows the hallmarks for being the driver of the genome-wide association studies for reduced risk of liver fibrosis and non-alcoholic fatty liver disease at MERTK. 27577861 2017
CUI: C0239946
Disease: Fibrosis, Liver
Fibrosis, Liver 		0.050 Biomarker disease BEFREE MERTK and PCSK7 SNPs were not associated with liver fibrosis or cirrhosis. 28338112 2017