|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These data point to the individuality of gene expression of molecules with CEA determinants both in fetal development and in early neoplasia.
|
61812 |
1976 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
No correlation could be found between Broder's grade or Duke's classification of the original tumor and modal chromosome number or ability to synthesize CEA.
|
1000501 |
1976 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Twenty-three family members were screened for the tumor with carcinoembryonic antigen (CEA) assay, barium enema, and proctoscopy; one occult colon cancer was diagnosed.
|
1253119 |
1976 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A two- to fourfold higher expression of CEA mRNA (3.6 kb) was observed in 11 of 22 colorectal tumors (2 of 9 proximal colon tumors and 9 of 14 rectosigmoid tumors) when compared with morphologically normal adjacent mucosae.
|
1290028 |
1992 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Carcinoembryonic antigen (CEA), a tumor marker for lung cancers of small cell (SCLC) and non-small cell (NSCLC) types, belongs in a multigene family which includes non-specific cross-reacting antigen (NCA) and biliary glycoprotein 1 (BGP).
|
1330929 |
1992 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The epitopes for the Group F MAbs were retained on the CEA molecules in the plasma of patients with malignant tumors and on the CEA molecules spontaneously released into the culture media from established tumor cell lines.
|
1377668 |
1992 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Hitherto anti-CEA monoclonal antibodies (MAbs), normally of mouse origin, have been used primarily for clinical diagnosis of colorectal cancer, either as a tumor marker in serum to monitor tumor recurrence, or latterly as a means to localize in vivo CEA-bearing tumors, and metastases in patients.
|
1431347 |
1992 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
When grafted into immunocompetent syngeneic BDIX rats, the CEA-expressing clones induced a strong antibody response against CEA and tumor rejections in a majority of the animals.
|
1500216 |
1992 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
For comparison with reg, alpha-1-antitrypsin (AAT), lysozyme, chromogranin A (CMG), CA 19-9, carcinoembryonic antigen (CEA), cytokeratin, vimentin, and alpha-fetoprotein (AFP) were assessed in those tumors.
|
1525759 |
1992 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Transcripts related to the human carcinoembryonic antigen were found in mRNA isolated from both dimethylbenzanthracene-induced and mouse mammary tumor virus-induced mammary tumors.
|
1653760 |
1991 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The elevated CEA values (greater than or equal to 5.0 micrograms/l) correlated with tumour stage in patients with aneuploid tumours but not in patients with diploid tumours.
|
1771385 |
1991 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunocytochemistry and radioimmunoassay showed production of tumor marker antigens (carcinoembryonic antigen, CA 19-9, and sialyl-Lex-i) and gastrin in both lines.
|
1846312 |
1991 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunocytochemistry for calcitonin and carcinoembryonic antigen as well as flow cytometry for DNA ploidy may be valuable techniques to assess prognosis of these tumors.
|
1928560 |
1991 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These data suggest that NCA may be more useful as a tumor marker for colon carcinoma than CEA at the level of mRNA, and that transcriptions of the CEA and NCA genes might be regulated by some common mechanisms in malignant and nonmalignant tissues of the colon.
|
2067130 |
1991 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Therefore, the highly differentiated LS174T cell line and the poorly differentiated MIP cell line represent colorectal tumor cell types that are unresponsive to the ability of IFN-gamma to induce alterations in tumor (i.e., CEA) or normal (i.e., class I and class II human leucocyte antigen) surface antigen expression.
|
2119252 |
1990 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
No correlation between tissue CEA and tumor differentiation could be found, but there was a significant difference between aneuploid (747 +/- 354 ng/mg) and diploid (139 +/- 43 ng/mg) tumors.
|
2317759 |
1990 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunocytochemical staining was negative for beta-subunit human chorionic gonadotrophin but positive for carcinoembryonic antigen only in areas of squamous differentiation.All three tumors bound peanut lectin.
|
2418959 |
1986 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, the demonstration that HuIFN-gamma enhances CEA expression in some carcinoma cell lines but fails to induce de novo expression of CEA transcripts in fibroblasts supports the potential application of HuIFN-gamma in enhancement of tumor targeting of antitumor MAbs and adds to our understanding of the mechanism of gamma-interferon-mediated up-regulation of some tumor antigens.
|
2496918 |
1989 |
|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Southern blot analysis of human normal and tumor DNA, using as probes two lambda 39.2 fragments that contain coding sequences, suggests the existence of 9-11 genes for the CEA family.
|
3033672 |
1987 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Carcinoembryonic antigen (CEA) is a glycoprotein which is important as a tumor marker for a number of human cancers.
|
3356015 |
1988 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
No CEA was present either by radioimmunoassay (RIA) of the culture supernatant or by immunoperoxidase staining of the tumors or monolayers.
|
3442732 |
1987 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thirty-eight patients with AN and 28 patients with ND tumors were operated on for cure and had normal plasma CEA levels postoperatively.
|
3568033 |
1987 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, the tumor xenografts differentially expressed carcinoembryonic antigen, human pancreas cancer-associated antigen, and human pancreas-specific antigen.
|
3754176 |
1986 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The values obtained were related to tumor characteristics such as Dukes' stage, differentiation, DNA ploidy pattern, expression of secretory component (SC), volume, and plasma level of carcinoembryonic antigen (CEA).
|
3802011 |
1987 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Both assays showed a similar number of 'false-negative' CEA levels pre-operatively--varying from 69% in aneuploid (AN) Dukes' A to 8% in AN Dukes' D tumours, and from 75% in near diploid (ND) Dukes' A to 40% in ND Dukes' D tumours.
|
3816909 |
1986 |