Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Twenty-three family members were screened for the tumor with carcinoembryonic antigen (CEA) assay, barium enema, and proctoscopy; one occult colon cancer was diagnosed.
|
1253119 |
1976 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
No correlation could be found between Broder's grade or Duke's classification of the original tumor and modal chromosome number or ability to synthesize CEA.
|
1000501 |
1976 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These data point to the individuality of gene expression of molecules with CEA determinants both in fetal development and in early neoplasia.
|
61812 |
1976 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
By sedimentation of poly(A)-containing tumor RNA through a sucrose gradient, and by in vitro translation of each fraction of the gradient, the sedimentation coefficient of CEA-specific mRNA was found to be about 22 S.
|
6200032 |
1983 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
T3M-4 cells possess the characteristic function of CEA secretion in vitro in culture and in vivo in nude mice bearing the tumors produced by inoculation with the cultured cells.
|
6821838 |
1983 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The tumor cell populations were analyzed for cellular proliferation (labeling index, agar clonogenicity, and self-renewal capacity), for cell differentiation (cell surface expression of carcinoembryonic antigen and histochemical stain for fat accumulation), and for karyotypic changes.
|
6848199 |
1983 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Carcinoembryonic antigen, a tumor-associated glycoprotein induces defective lymphocyte function.
|
6236377 |
1984 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Serum CEA rose linearly as the tumors enlarged; however, the concentration of CEA per g of extracted tumor remained constant throughout the weight range studied.
|
6498810 |
1984 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Both assays showed a similar number of 'false-negative' CEA levels pre-operatively--varying from 69% in aneuploid (AN) Dukes' A to 8% in AN Dukes' D tumours, and from 75% in near diploid (ND) Dukes' A to 40% in ND Dukes' D tumours.
|
3816909 |
1986 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, the tumor xenografts differentially expressed carcinoembryonic antigen, human pancreas cancer-associated antigen, and human pancreas-specific antigen.
|
3754176 |
1986 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunocytochemical staining was negative for beta-subunit human chorionic gonadotrophin but positive for carcinoembryonic antigen only in areas of squamous differentiation.All three tumors bound peanut lectin.
|
2418959 |
1986 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Southern blot analysis of human normal and tumor DNA, using as probes two lambda 39.2 fragments that contain coding sequences, suggests the existence of 9-11 genes for the CEA family.
|
3033672 |
1987 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The values obtained were related to tumor characteristics such as Dukes' stage, differentiation, DNA ploidy pattern, expression of secretory component (SC), volume, and plasma level of carcinoembryonic antigen (CEA).
|
3802011 |
1987 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
No CEA was present either by radioimmunoassay (RIA) of the culture supernatant or by immunoperoxidase staining of the tumors or monolayers.
|
3442732 |
1987 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Thirty-eight patients with AN and 28 patients with ND tumors were operated on for cure and had normal plasma CEA levels postoperatively.
|
3568033 |
1987 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Carcinoembryonic antigen (CEA) is a glycoprotein which is important as a tumor marker for a number of human cancers.
|
3356015 |
1988 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In addition, the demonstration that HuIFN-gamma enhances CEA expression in some carcinoma cell lines but fails to induce de novo expression of CEA transcripts in fibroblasts supports the potential application of HuIFN-gamma in enhancement of tumor targeting of antitumor MAbs and adds to our understanding of the mechanism of gamma-interferon-mediated up-regulation of some tumor antigens.
|
2496918 |
1989 |
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Therefore, the highly differentiated LS174T cell line and the poorly differentiated MIP cell line represent colorectal tumor cell types that are unresponsive to the ability of IFN-gamma to induce alterations in tumor (i.e., CEA) or normal (i.e., class I and class II human leucocyte antigen) surface antigen expression.
|
2119252 |
1990 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
No correlation between tissue CEA and tumor differentiation could be found, but there was a significant difference between aneuploid (747 +/- 354 ng/mg) and diploid (139 +/- 43 ng/mg) tumors.
|
2317759 |
1990 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Transcripts related to the human carcinoembryonic antigen were found in mRNA isolated from both dimethylbenzanthracene-induced and mouse mammary tumor virus-induced mammary tumors.
|
1653760 |
1991 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunocytochemistry for calcitonin and carcinoembryonic antigen as well as flow cytometry for DNA ploidy may be valuable techniques to assess prognosis of these tumors.
|
1928560 |
1991 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Immunocytochemistry and radioimmunoassay showed production of tumor marker antigens (carcinoembryonic antigen, CA 19-9, and sialyl-Lex-i) and gastrin in both lines.
|
1846312 |
1991 |
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The elevated CEA values (greater than or equal to 5.0 micrograms/l) correlated with tumour stage in patients with aneuploid tumours but not in patients with diploid tumours.
|
1771385 |
1991 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These data suggest that NCA may be more useful as a tumor marker for colon carcinoma than CEA at the level of mRNA, and that transcriptions of the CEA and NCA genes might be regulated by some common mechanisms in malignant and nonmalignant tissues of the colon.
|
2067130 |
1991 |
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
A two- to fourfold higher expression of CEA mRNA (3.6 kb) was observed in 11 of 22 colorectal tumors (2 of 9 proximal colon tumors and 9 of 14 rectosigmoid tumors) when compared with morphologically normal adjacent mucosae.
|
1290028 |
1992 |