Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In prostate adenocarcinoma, besides mutations in BRCA1 and BRCA2 genes that are known to increase the incidence of high-risk cancer in young patients, new studies have shown mutation in other gene such as HOXB13 and also polymorphisms in MYC, MSMB, KLK2 and KLK3 that can be related to hereditary prostate cancer.
|
27819754 |
2017 |
Prostate cancer, familial
|
0.600 |
Biomarker
|
disease |
BEFREE |
Computational Modeling of complete HOXB13 protein for predicting the functional effect of SNPs and the associated role in hereditary prostate cancer.
|
28272408 |
2017 |
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In silico analysis of the deleterious nsSNPs (missense) in the homeobox domain of human HOXB13 gene responsible for hereditary prostate cancer.
|
28072499 |
2017 |
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A recurrent mutation in HOXB13 has been shown to predispose to hereditary prostate cancer (HPC), and BRCA2 mutations to hereditary breast and ovarian cancer (HBOC).
|
27899188 |
2016 |
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A rare recurrent missense variant in HOXB13 (rs138213197/rs138213197" genes_norm="10481">G84E) was recently reported to be associated with hereditary prostate cancer.
|
25595936 |
2015 |
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Recent genetic epidemiologic studies identified a germline mutation in the homeobox transcription factor, HOXB13 G84E, which is associated with markedly increased risk for prostate cancer, particularly early-onset hereditary prostate cancer.
|
24722062 |
2014 |
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
A rare but recurrent missense mutation (rs138213197" genes_norm="10481">G84E, rs138213197) in the gene homeobox B13 (HOXB13) was recently reported to be associated with hereditary prostate cancer.
|
22841674 |
2014 |
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Men with the HOXB13 G84E variant had a 4.51-fold higher relative risk of PCa compared with non-carriers (95 % CI 3.28-6.20).
|
24026887 |
2014 |
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The HOXB13 mutation substantially increases risk of early onset, familial prostate cancer in European-American men.
|
23396964 |
2013 |
Prostate cancer, familial
|
0.600 |
Biomarker
|
disease |
CTD_human |
The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer.
|
22236224 |
2012 |
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer.
|
22236224 |
2012 |
Prostate cancer, familial
|
0.600 |
SusceptibilityMutation
|
disease |
ORPHANET |
The novel HOXB13 G84E variant is associated with a significantly increased risk of hereditary prostate cancer.
|
22236224 |
2012 |
Prostate cancer, familial
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the rs138213197" genes_norm="10481">G84E germline mutation (rs138213197) of HOXB13 in a case-control study of familial prostate cancer at Vanderbilt University (Nashville, TN) to independently evaluate the association of the mutation with familial prostate cancer.
|
22714738 |
2012 |