NXF1, nuclear RNA export factor 1, 10482

N. diseases: 141; N. variants: 0
Disease: Nagana ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027333
Disease: Nagana
Nagana 		0.010 Biomarker disease BEFREE Using protein sequence alignments and structure prediction modeling, we show that TbMex67 lacks the amino acids previously shown to be essential for binding to 5S rRNA in yeast and in general aligns more closely with the human orthologue (NXF1 or TAP).This work suggests that the <i>T. brucei</i> Mex67-Mtr2 binds ribosomal cargo differently from the yeast system.<b>IMPORTANCE</b><i>Trypanosoma brucei</i> is the causative agent for both African sleeping sickness in humans and nagana in cattle. 31413174 2019