NCOA2, nuclear receptor coactivator 2, 10499

N. diseases: 95; N. variants: 8
Disease: Prostate carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.080 Biomarker disease BEFREE Further secondary and tertiary hit characterization assays are underway to select AR-TIF2 PPI inhibitor/disruptor hits suitable for medicinal chemistry lead optimization and development into novel PCa/CRPC therapeutics. 30109944 2019
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.080 Biomarker disease BEFREE Furthermore, for the first time, we detected a structural rearrangement involving NCOA2 in PCa. 26799514 2016
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.080 Biomarker disease BEFREE Concordant assessment of DNA copy number, mRNA expression, and focused exon resequencing in 218 prostate cancer tumors identified the nuclear receptor coactivator NCOA2 as an oncogene in approximately 11% of tumors. 20579941 2010
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.080 Biomarker disease BEFREE Interleukin-6 increases prostate cancer cells resistance to bicalutamide via TIF2. 19240160 2009
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.080 AlteredExpression disease BEFREE Depletion of TIF2 reduced expression of AR-induced target genes and slowed proliferation of AR-dependent and AR-independent prostate cancer cells. 17079484 2006
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.080 AlteredExpression disease BEFREE Cofactors SRC-1, RAC3, p300/CBP, TIF-2, and Tip60 are upregulated in advanced prostate cancer. 16598769 2006
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.080 AlteredExpression disease BEFREE AR coactivators SRC-1 and TIF-2 are up-regulated in tissue specimens obtained from patients who failed prostate cancer endocrine therapy. 15663989 2004
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.080 AlteredExpression disease BEFREE The three coactivators, TIF-2, SRC-1 and RAC3, are up-regulated in relapsed prostate cancer. 12237244 2002