|
Liver carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
In this report, we activate CEPBA with saRNAs and suppress CEBPB with siRNAs in cells that represent three different degrees of HCC.
|
30643190 |
2019 |
|
Liver carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Liver-enriched activator protein 1 as an isoform of CCAAT/enhancer-binding protein beta suppresses stem cell features of hepatocellular carcinoma.
|
29731667 |
2018 |
|
Liver carcinoma
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Our results indicated that rs12309362 (G > A), rs9970827 (A > G) in DHSs, and elevated expression of CEBPB were associated with a decreased risk of HCC.
|
28321907 |
2017 |
|
Liver carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Orosomucoid 2 inhibits tumor metastasis and is upregulated by CCAAT/enhancer binding protein β in hepatocellular carcinomas.
|
25965830 |
2015 |
|
Liver carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
In this study, we sought to determine the molecular mechanism of the tumor suppression activity of a short RNA from 3'UTR of C/EBPβ mRΝΑ (C/EBPβ 3'UTR RNA) in human hepatocarcinoma cells SMMC-7721.
|
21283634 |
2011 |
|
Liver carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
In this study, we used the opposing transcriptional effects driven by LAP and LIP to determine the genuine C/EBPbeta molecular signature in the Hep3B human hepatoma cell line.
|
21145827 |
2011 |
|
Liver carcinoma
|
0.390 |
Biomarker
|
disease |
CTD_human |
Dietary alpha-linolenic acid reduces COX-2 expression and induces apoptosis of hepatoma cells.
|
14563831 |
2004 |
|
Liver carcinoma
|
0.390 |
Biomarker
|
disease |
LHGDN |
Transfection of cDNA in 3'untranslated region of human nuclear factor for interleukin-6 (NF-IL6 3'UTR) induced tumor suppression in a human hepatoma cell line. cDNA array analysis was used to reveal changes in gene expression profile leading to tumor suppression The results indicate that this suppression was not due to activation of dsRNA-dependent protein kinase, nor to inactivation of oncogenes; rather, all the changes in expression of known genes, induced by NF-IL6 3'UTR cDNA may be ascribed to the suppression of cellular malignancy.
|
14728809 |
2003 |
|
Liver carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Previous studies have shown that in human T-cells (Jurkat) and hepatoma cells (HepG2), exogenous NF-IL6 can activate HIV-1 gene expression even in the absence of its consensus binding elements in the viral long terminal repeat (LTR).
|
8844998 |
1996 |
|
Liver carcinoma
|
0.390 |
Biomarker
|
disease |
BEFREE |
Among these, IL-6DBP/NF-IL6 plays a key role in IL-6 signal transduction because its trans-activation potential is induced by IL-6 in the human hepatoma cell line Hep3B.
|
7680115 |
1993 |
|
Pulmonary Fibrosis
|
0.320 |
Biomarker
|
disease |
BEFREE |
Our study indicates that a regulatory mechanism of the GSK-3β-A20-C/EBPβ axis in AMs may be a potential target for treating PF and fibroproliferative lung diseases.
|
31471107 |
2019 |
|
Pulmonary Fibrosis
|
0.320 |
Biomarker
|
disease |
BEFREE |
Phosphorylation of human C/EBPβ on Thr266 (human homologue phosphoacceptor) was induced in collagen-activated human lung fibroblasts in culture as well as in activated lung fibroblasts in situ in lungs of patients with severe lung fibrosis but not in control lungs, suggesting that this signaling pathway may be also relevant in human lung injury and fibrosis.
|
21998664 |
2011 |
|
Pulmonary Fibrosis
|
0.320 |
Biomarker
|
disease |
CTD_human |
An essential role for CCAAT/enhancer binding protein beta in bleomycin-induced pulmonary fibrosis.
|
17177178 |
2007 |
|
Steatohepatitis
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
CXCL10 was linked to steatosis through upregulation of the lipogenic factors SREBP-1c and LXR, and also to oxidative stress (upregulation of CYP2E1 and C/EBPβ).
|
25048951 |
2014 |
|
Steatohepatitis
|
0.310 |
Biomarker
|
disease |
CTD_human |
A simple transcriptomic signature able to predict drug-induced hepatic steatosis.
|
24469900 |
2014 |
|
Fatty Liver
|
0.300 |
Biomarker
|
disease |
CTD_human |
A simple transcriptomic signature able to predict drug-induced hepatic steatosis.
|
24469900 |
2014 |
|
Female infertility
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
CCAAT/enhancer-binding proteins (C/EBP)-α and -β are essential for ovulation, luteinization, and the expression of key target genes.
|
21177758 |
2011 |
|
Sterility, Postpartum
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
CCAAT/enhancer-binding proteins (C/EBP)-α and -β are essential for ovulation, luteinization, and the expression of key target genes.
|
21177758 |
2011 |
|
Subfertility, Female
|
0.300 |
Biomarker
|
disease |
CTD_human |
CCAAT/enhancer-binding proteins (C/EBP)-α and -β are essential for ovulation, luteinization, and the expression of key target genes.
|
21177758 |
2011 |
|
Female sterility
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
CCAAT/enhancer-binding proteins (C/EBP)-α and -β are essential for ovulation, luteinization, and the expression of key target genes.
|
21177758 |
2011 |
|
Brain Ischemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents.
|
17394460 |
2007 |
|
Cerebral Ischemia
|
0.300 |
Biomarker
|
disease |
CTD_human |
Peroxisome proliferator-activated receptor-gamma agonists induce neuroprotection following transient focal ischemia in normotensive, normoglycemic as well as hypertensive and type-2 diabetic rodents.
|
17394460 |
2007 |
|
Alveolitis, Fibrosing
|
0.300 |
Biomarker
|
disease |
CTD_human |
An essential role for CCAAT/enhancer binding protein beta in bleomycin-induced pulmonary fibrosis.
|
17177178 |
2007 |
|
Virus Diseases
|
0.250 |
AlteredExpression
|
group |
BEFREE |
We hypothesize that dengue virus infection of the liver cells may trigger both an oxidant-dependent and an oxidant-independent pathway to up-regulate RANTES mRNA expression through activating NF-IL-6 and an undefined factor, respectively.
|
11022000 |
2000 |
|
Virus Diseases
|
0.250 |
Biomarker
|
group |
BEFREE |
Thus, NF-IL6 may play a significant role in the regulation of viral transcription as a part of the host's resistance to viral infection.
|
8380454 |
1993 |