The results showed that four SNPs (<i>LACC1</i>/rs9316059, <i>CEBPB-PTPN1</i>/rs913678, <i>ADO-EGR2</i>/rs224127 and <i>RIPK2</i>/rs10094579) were associated with BD in an allelic association test (rs9316059 T allele: p<sub>c</sub>=4.95×10<sup>-8</sup>, OR=0.687; rs913678 C allele: p<sub>c</sub>=3.01×10<sup>-4</sup>, OR=1.297; rs224127 A allele: p<sub>c</sub>=3.77×10<sup>-4</sup>, OR=1.274; rs10094579 A allele: p<sub>c</sub>=6.93×10<sup>-4</sup>, OR=1.302).
The activating transcription factor 3 (ATF3) transcript level was increased in PBMCs from patients with stable BD compared to that in PBMCs from HCs. siRNAs targeting C/EBPβ and C/EBPδ significantly reduced the production of IL-6 and TNF-α in lipopolysaccharide-stimulated CD11b+ cells from patients with BD as well as from HCs.