CEBPB, CCAAT enhancer binding protein beta, 1051

N. diseases: 182; N. variants: 1
Disease: Sepsis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0243026
Disease: Sepsis
Sepsis 		0.240 AlteredExpression disease BEFREE We previously reported that the transcription factors Stat3 and C/EBPβ synergize to induces the expression of microRNA (miR)-21 and miR-181b to promote MDSC expansion in a mouse model of polymicrobial sepsis that progresses from an early/acute proinflammatory phase to a late/chronic immunosuppressive stage. 31078118 2019
CUI: C0243026
Disease: Sepsis
Sepsis 		0.240 Biomarker disease BEFREE Adoptive transfer of C/EBPβ-deficient Gr1<sup>+</sup>CD11b<sup>+</sup> cells from late septic mice exacerbated inflammation in control mice undergoing early sepsis, confirming they were not immunosuppressive. 28476751 2017
CUI: C0243026
Disease: Sepsis
Sepsis 		0.240 AlteredExpression disease BEFREE Expression of C/EBPβ in myeloid progenitors during sepsis promotes immunosuppression. 28934717 2017
CUI: C0243026
Disease: Sepsis
Sepsis 		0.240 Biomarker disease BEFREE Mechanistically, transcription factor Rb phosphorylation supports Stat3 and C/EBPβ accumulation at both miRNA promoters, and C/EBPβ or Stat3 depletion by siRNA in sepsis Gr1<sup>+</sup>CD11b<sup>+</sup> MDSCs inhibits miR-21 and miR-181b expression. 27430527 2017
CUI: C0243026
Disease: Sepsis
Sepsis 		0.240 Biomarker disease RGD C/EBP DNA-binding activity is upregulated by a glucocorticoid-dependent mechanism in septic muscle. 11792653 2002