|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Through an unbiased genetic screen, we found that heterozygosity for <i>Enhancer of Polycomb</i> [<i>E(Pc)</i>], a component of the Tip60 lysine acetyltransferase complex (also known as KAT5 in humans), significantly increased tumor burden in <i>hop<sup>Tum</sup></i> animals.
|
31072879 |
2019 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In the xenografts, the tumor weight and volume were notably reduced due to the downregulation of Tip60 expression.
|
30936993 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
A significant association of specific Tip60 staining patterns with breast cancer subtype, ER or PR status and Tumour grade was found.
|
30846725 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The function of TIP60 in tumor development has not been fully understood.
|
29174981 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We developed a user-friendly one-stop shop web tool called TIP to comprehensively resolve tumor immunophenotype.
|
30154154 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This is evidence that the underexpression of TIP60 observed in breast cancer can promote the tumorigenesis of ER-negative tumors.
|
30324811 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
TIP60 is a lysine acetyltransferase and is known to be a haplo-insufficient tumor suppressor.
|
30053221 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tip60, as a tumor suppressor in CCA via the PI3K/AKT pathway, might be a promising therapeutic target or prognostic marker for CCA.
|
30308494 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Furthermore, compared to paired tumor-adjacent tissue, lung cancer tumors had low expression of TIP60.
|
28819431 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
HIV1-TAT interactive protein (TIP60) is a haploinsufficient tumor suppressor.
|
29045464 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Low Tip60 reduces DNA repair in normal and tumor mammary epithelial cells, both under resting conditions and following genotoxic stress.
|
26915295 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We demonstrate for the first time that tumor suppressor Tip60 down-regulates cell adhesion and MT1-MMP expression and thereby invasion of glioblastoma cells by suppressing NF-κB pathway.
|
26464124 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The tumor suppressor Tip60 regulates gene transcription, DNA damage response, apoptosis, and cancer development, but its role in melanoma is unknown.
|
22673729 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Differences in expression profiles were also found to exist between individual breast tumors and, in some cases, were significantly associated with conventional pathological parameters and prognostic indices: tumor grade (K (lysine) acetyltransferase 5 (KAT5), HDAC1, KDM4A, SUV39H1 and KDM6A)); TNM stage (SUV39H1, K (lysine) acetyltransferase 2B (KAT2B), lysine (K)-specific demethylase 1A (KDM1A), KDM4A, lysine (K)-specific demethylase 5C (KDM5C), K (lysine) acetyltransferase 8 (KAT8), HDAC5 and KAT5)); Nottingham Prognostic Index (KDM5C, myeloid/lymphoid or mixed-lineage leukemia (MLL), KAT8 and SET and MYND domain containing 3 (SMYD3)); receptor status (KAT5, SMYD3 and KDM1A); histological type (KAT5, KDM5C, KAT8, KDM4A and MLL); disease-free survival (SUV39H1, SMYD3, HDAC5, KDM6A, HDAC1, KDM1A, KDM4A, KAT8, KDM5C, KAT5 and MLL) and overall survival (KAT8).
|
22199269 |
2011 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, Axin is a critical determinant in p53-dependent tumour suppression in which Pirh2 and Tip60 have different roles in triggering cell-cycle arrest or apoptosis depending on the severity of genotoxic stress.
|
19731416 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Tip60 down-regulation showed significant correlation with larger tumor size (p=0.0005), poorly differentiated type (p=0.0394), peritoneal dissemination (p=0.0053), distant metastasis (p=0.0394), and higher stage of TNM classification (p=0.0226).
|
19846935 |
2009 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
These results, coupled with the inhibition of the cell proliferation by electroporation of melanoma cells with cPLA(2) or COX-2 antibodies, demonstrate that a possible correlation between PLA(2)-COX expression and tumor cell proliferation in the melanocytic system does exist.
|
18722548 |
2008 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Tip60 is a haplo-insufficient tumour suppressor required for an oncogene-induced DNA damage response.
|
17728759 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Compared with normal littermate skin, we detected altered association of Tip60 with E2F1 and a subset of newly identified Tip60-interacting transcription factors in ODC transgenic mouse skin and tumors.
|
16912189 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Although high levels of cPLA(2) and COX-2 expression are predicted to facilitate maximal prostaglandin production, tumors frequently displayed a high-COX-2/low-cPLA(2) phenotype.
|
15788676 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Elevated levels of sPLA(2) and cPLA(2) have been reported in several tumour types.
|
12927514 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We analysed the gene expression of cPLA(2) and sPLA(2)-X in 42 and 38 primary colorectal tumours, respectively, with and without K-ras mutations.
|
12048163 |
2002 |