KAT5, lysine acetyltransferase 5, 10524

N. diseases: 138; N. variants: 6
Disease: Tumor Progression ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.040 Biomarker phenotype BEFREE Moreover, recent works have demonstrated the role of Tip60 in cancer progression. 29549519 2018
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.040 Biomarker phenotype BEFREE However, the role of Tip60 in cancer progression remains contradictory. 30308494 2018
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.040 AlteredExpression phenotype BEFREE Strikingly, reversing the p400/Tip60 imbalance by Tip60 overexpression or the use of siRNAs resulted in increased apoptosis and decreased proliferation of colon-cancer-derived cells, suggesting that this ratio defect is important for cancer progression. 19169279 2009
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.040 Biomarker phenotype BEFREE Second, Tip60 modulates DNA-damage response (DDR) signalling, and a DDR triggered by oncogenes can counteract tumour progression. 17728759 2007