IPO8, importin 8, 10526

N. diseases: 20; N. variants: 4
Disease: Liver carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.010 Biomarker disease BEFREE To further elucidate the mechanism of CASE, the effects of CASE on TGF-β<sub>1</sub>, the serine/threonine kinase receptors of TGF-β [TGF-β receptor type-I (TβRI) and TβRII] and karyopherins [Importin 7 (Imp7) and Imp8], which are crucial for TGF-β/Smad signaling in fibro-hepatocarcinogenesis, were assessed in the present study using <i>in vivo</i> (DEN-induced HCC in rats) and <i>in vitro</i> [TGF-β<sub>1</sub>-stimulated rat myofibroblasts (MFBs) and HepG2 cells] models of fibro-hepatocarcinogenesis. 30112050 2018