|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In conclusion, our in vivo results indicate that Dis significantly reduces tumor growth rate of HCT-116 colon cancer cells in nude mice at a dose of 100 mg/kg, and has no toxic effects in ICR mice up to 2000 mg/kg.
|
31295840 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This synergistic NO-CDT effect has been proved to retard the tumor growth in Heps xenograft ICR mouse models.
|
30919635 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
An allograft tumor model was also established in another ICR mouse group.
|
30564277 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In an <i>in vivo</i> xenograft model of ICR-SCID mice implanted with HCT116 cells, 200 mg/kg TP4O was injected locally, and tumor growth was compared with that of the control.
|
28781645 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Sphere formation assays were performed to investigate stem cell properties of tumor cellsin vitro Retrospective and prospective studies were used to investigate the relationship between ICR expression and clinical outcomes.
|
26667486 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In vivo, ICR mice carrying tumor of hepatoma H22 cells were treated via intratumoral injection of chimeric virus.
|
27164362 |
2016 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The same tissues were also used for global lipid profiling analysis by MALDI-FT-ICR MS. From the cumulative protein and lipid expression profile data, a refined panel of 26 proteins and 39 lipid species was identified that could either distinguish tumor from nontumor tissues, or tissues from recurrent disease progressors from nonrecurrent disease individuals.
|
24497498 |
2014 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This compound also showed in vivo activity against multiple myeloma cell line KMS34 tumor xenografts in ICR/SCID mice.
|
22761710 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Eukaryotic expressing vectors pIRES2, encoding Talpha1 and/or interferon omega1, were constructed and injected with liposome via the tail vein into ICR mice bearing a Hep-A-22 tumor.
|
16928214 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
For these experimental purposes five main classes of experimental models are available: spontaneous endometrial tumorigenesis models in inbred animals (Donryu rats, DA/Han rats, BDII/Han rats), inoculation tumors from chunks of tumors (rat EnDA-tumor, human EnCa 101 tumor) or from inoculated tumor cell lines (rat RUCA-I cells, human Ishikawa and ECC-1 cells), developmental estrogenic exposure or chemical carcinogen exposure of CD-1 and ICR mice, transgenic approaches such as mice heterozygous regarding the tumor suppressor gene PTEN (pten(+/-)-mice) and endometrial tumor cell lines cultured under conditions promoting in vivo-like morphology and functions e.g. cell culture on reconstituted basement membrane.
|
12653669 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
K14.COX2 transgenics developed tumors at a much lower frequency than did their littermate controls (3.3% versus 93%, respectively, on a FVB background and approximately 25% versus 100%, respectively, on an ICR background) and presented with significantly reduced tumor burdens (average, 0.03 versus 12.7 tumors/mouse, respectively, on a FVB background and 0.5 versus 7.1 tumors/mouse, respectively, on an ICR background).
|
11980643 |
2002 |
|
Carcinogenesis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
In order to understand the gender difference effects of ER during carcinogenesis of lung induced by arsenic, the effects of arsenic and estrogen receptor antagonist (ICI182780) on expression levels of estrogen receptor beta (ERβ), extracellular regulated protein kinase (ERK1/2) and nuclear factor κB (NF-κB/P65) in type II alveolar epithelial cells (AECII) from different sex ICR fetal mice lung were detected.
|
30684567 |
2019 |
|
Carcinogenesis
|
0.070 |
AlteredExpression
|
phenotype |
BEFREE |
Modified apple polysaccharide influences MUC-1 expression to prevent ICR mice from colitis-associated carcinogenesis.
|
30266641 |
2018 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
In this study, we investigated the preventive effect of PMFs on benzo[a]pyrene/dextran sulfate sodium (BaP/DSS)-induced colorectal tumorigenesis in ICR mice.
|
29197069 |
2018 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
Annona muricata leaves extracts prevent DMBA/TPA-induced skin tumorigenesis via modulating antioxidants enzymes system in ICR mice.
|
28779710 |
2017 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
The combination not only protected ICR mice against intestinal toxicities and carcinogenesis induced by 1,2-dimethylhydrazine and dextran sodium sulfate, but also decreased the xenograft tumor size, triggered apoptosis and inhibited proliferation of tumor cells in nude mice.
|
28389232 |
2017 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
The effect of consumption of 2% or 10% cooked chickpeas on carcinogenesis-induced colon azoxymethane (AOM)/dextran sulfate sodium (DSS) in ICR mice was determined.
|
28657468 |
2017 |
|
Carcinogenesis
|
0.070 |
Biomarker
|
phenotype |
BEFREE |
The colitis‑associated tumorigenesis was induced in ICR mice by the administration of 1,2‑dimethyl hydrazine (DMH) and dextran sodium sulfate (DSS), termed the DMH + DSS group.
|
28713897 |
2017 |
|
Diabetes Mellitus
|
0.050 |
Biomarker
|
group |
BEFREE |
Six-week-old male ICR mice were divided into the following groups: Control, Control+DF (received 50 mg/kg DF), streptozotocin (STZ)-induced DM group, DM+Acarbose group (20 mg/kg of acarbose), DM+DF-L (25 mg/kg of DF), DM+DF-H (50 mg/kg of DF), and DM+APPH (50 mg/kg of APPH).
|
30987324 |
2019 |
|
Memory impairment
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
To investigate the novel therapeutic effects and molecular mechanism of GR on alleviation of cognitive impairment, two different dosages of gallotannin-enriched GR (GEGR) were administered to Korl:ICR mice for three weeks, and to induce memory impairment, scopolamine (SP) was administered during the last seven days of the GEGR treatment period.
|
31623364 |
2019 |
|
Memory impairment
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
It was also demonstrated pro-neurogenesis effects in ICR and APP/PS1 mice and improved memory deficit of APP/PS1 mice.
|
31257716 |
2019 |
|
Diabetes Mellitus
|
0.050 |
Biomarker
|
group |
BEFREE |
A total of 30 female ICR mice were divided into three groups: those with STZ-induced (STZ group) and AL-induced (AL group) diabetes, and a control group.
|
30550618 |
2018 |
|
Diabetes Mellitus
|
0.050 |
Biomarker
|
group |
BEFREE |
Male ICR mice were diabetes induced by STZ, and then oral administration of fermented products.
|
30311649 |
2018 |
|
Memory impairment
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
We used outbred ICR mice fed on high-fat diet (HFD) and performed the paired associates learning (PAL) test to detect their visual memory and new learning ability loss as well as to assess memory impairment.
|
30181690 |
2018 |
|
Diabetes Mellitus
|
0.050 |
Biomarker
|
group |
BEFREE |
Healthy ICR mice were divided into control group (n = 10) and db/db DM group (n = 10).
|
28223216 |
2017 |