PROCR, protein C receptor, 10544

N. diseases: 110; N. variants: 20
Disease: Severe Sepsis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.030 GeneticVariation disease BEFREE Endothelial protein C receptor polymorphisms and risk of severe sepsis in critically ill patients. 23881209 2013
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.030 Biomarker disease BEFREE These results suggest that the EPCR- and PAR-1-dependent protective effects of APC in severe sepsis may partially be mediated through the inhibition of HMGB1 signaling and that the chimeric thrombin mutant has potential therapeutic utility for severe sepsis. 21849480 2011
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis 		0.030 GeneticVariation disease BEFREE TNF-alpha 308 G/A, PAI-1 4G/4G, and EPCR mutations influence the risk of severe sepsis in children. 16444434 2006